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10.18632/oncotarget.14500 http://scihub22266oqcxt.onion/10.18632/oncotarget.14500 C5355265!5355265!28061465     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (7): 11284-301 Nephropedia Template TP {{tp|p=28061465|t=2017. SIRP?-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells |pdf=|usr=}}{{28061465}} gab.com Text SIRP -antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28061465 #FOAvip CD47, expressed on a variety of tumor cells, confers immune resistance by delivering an inhibitory ?don't eat me? signal to phagocytic cells via its myeloid-specific receptor SIRP?. Recent studies have shown that blocking the CD47-SIRP? axis with CD47-directed antibodies or antibody-derivatives enhances phagocytosis and increases antitumor immune effects. However, CD47 expression on healthy cells creates an antigen sink and potential sites of toxicity, limiting the efficacy of CD47-directed therapies. In this study, we first characterized CD47 expression in Acute Myeloid Leukemia (AML) patients (n = 213) and found that CD47 is highly expressed on both AML bulk and stem cells irrespective of the disease state. Furthermore, to inhibit the CD47-SIRP? signaling pathway at the tumor site, we developed a so-called local inhibitory checkpoint monoclonal antibody (licMAB) by grafting the endogenous SIRP? domain to the N-terminus of the light chain of an antibody targeting CD33, a surface antigen expressed in AML. LicMABs selectively bind CD33-expressing cells even in the presence of a large CD33-negative CD47-positive antigen sink, stimulate phagocytosis of AML cells and eliminate AML cell lines and primary, patient-derived AML cells. Our findings qualify licMABs as a promising therapeutic approach to confine the benefit of disrupting the CD47-SIRP? axis to tumor antigen-expressing cells. Twit Text FOAVip SIRP -antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28061465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28061465 #FOAvip English Wikipedia <ref>{{Cite pmid|28061465}}</ref> SIRP?-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells #MMPMID28061465 Ponce LP; Fenn NC; Moritz N; Krupka C; Kozik JH; Lauber K; Subklewe M; Hopfner KP Oncotarget 2017[Feb]; 8 (7): 11284-301 PMID28061465show ga CD47, expressed on a variety of tumor cells, confers immune resistance by delivering an inhibitory ?don't eat me? signal to phagocytic cells via its myeloid-specific receptor SIRP?. Recent studies have shown that blocking the CD47-SIRP? axis with CD47-directed antibodies or antibody-derivatives enhances phagocytosis and increases antitumor immune effects. However, CD47 expression on healthy cells creates an antigen sink and potential sites of toxicity, limiting the efficacy of CD47-directed therapies. In this study, we first characterized CD47 expression in Acute Myeloid Leukemia (AML) patients (n = 213) and found that CD47 is highly expressed on both AML bulk and stem cells irrespective of the disease state. Furthermore, to inhibit the CD47-SIRP? signaling pathway at the tumor site, we developed a so-called local inhibitory checkpoint monoclonal antibody (licMAB) by grafting the endogenous SIRP? domain to the N-terminus of the light chain of an antibody targeting CD33, a surface antigen expressed in AML. LicMABs selectively bind CD33-expressing cells even in the presence of a large CD33-negative CD47-positive antigen sink, stimulate phagocytosis of AML cells and eliminate AML cell lines and primary, patient-derived AML cells. Our findings qualify licMABs as a promising therapeutic approach to confine the benefit of disrupting the CD47-SIRP? axis to tumor antigen-expressing cells. äSIRP?-antibody fusion proteins stimulate phagocytosis and promote elim(epmc).pdf DeepDyve Pubget Overpricing