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10.18632/oncotarget.14495 http://scihub22266oqcxt.onion/10.18632/oncotarget.14495 C5355260!5355260 !28061440     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28061440 &cmd=llinks): Failed to open stream: HTTP request failed! 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IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma |pdf=|usr=}}{{28061440 }} gab.com Text IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28061440 #FOAvip The acquisition of radioresistance by esophageal squamous carcinoma (ESC) cells during radiotherapy may lead to cancer recurrence and poor survival. Previous studies have demonstrated that ionizing radiation (IR) induces epithelial-mesenchymal transition (EMT) of ESC cells accompanied by increased migration, invasion, and radioresistance. However, the underlying molecular mechanisms of IR-induced EMT and radioresistance are not well established, hampering the development of potential solutions. To address this issue, we investigated the role of the IL-6/STAT3/TWIST signaling pathway in IR-induced EMT. We found not only the pathway was activated during IR-induced EMT but also STAT3 inhibition or Twist depletion reversed the EMT process and attenuated radioresistance. These results improve our understanding of the underlying mechanisms involved in IR-induced EMT and suggest potential interventions to prevent EMT-induced acquisition of radioresistance. Twit Text FOAVip IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28061440 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28061440 #FOAvip English Wikipedia <ref>{{Cite pmid|28061440 }}</ref> IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma #MMPMID28061440 Zang C ; Liu X ; Li B ; He Y ; Jing S ; He Y ; Wu W ; Zhang B ; Ma S ; Dai W ; Li S ; Peng Z Oncotarget 2017[Feb]; 8 (7 ): 11228-11238 PMID28061440 show ga The acquisition of radioresistance by esophageal squamous carcinoma (ESC) cells during radiotherapy may lead to cancer recurrence and poor survival. Previous studies have demonstrated that ionizing radiation (IR) induces epithelial-mesenchymal transition (EMT) of ESC cells accompanied by increased migration, invasion, and radioresistance. However, the underlying molecular mechanisms of IR-induced EMT and radioresistance are not well established, hampering the development of potential solutions. To address this issue, we investigated the role of the IL-6/STAT3/TWIST signaling pathway in IR-induced EMT. We found not only the pathway was activated during IR-induced EMT but also STAT3 inhibition or Twist depletion reversed the EMT process and attenuated radioresistance. These results improve our understanding of the underlying mechanisms involved in IR-induced EMT and suggest potential interventions to prevent EMT-induced acquisition of radioresistance. |Animals [MESH] |Apoptosis/genetics/radiation effects [MESH] |Blotting, Western [MESH] |Carcinoma, Squamous Cell/*genetics/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Survival/genetics/radiation effects [MESH] |Epithelial-Mesenchymal Transition/*genetics/radiation effects [MESH] |Esophageal Neoplasms/*genetics/metabolism/pathology [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/radiation effects [MESH] |Humans [MESH] |Interleukin-6/*genetics/metabolism [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Microscopy, Fluorescence [MESH] |Nuclear Proteins/*genetics/metabolism [MESH] |RNA Interference [MESH] |Radiation, Ionizing [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |STAT3 Transcription Factor/*genetics/metabolism [MESH] |Signal Transduction/genetics/radiation effects [MESH] |Transplantation, Heterologous [MESH]IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT an(epmc).pdf DeepDyve Pubget Overpricing