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10.18632/oncotarget.14640 http://scihub22266oqcxt.onion/10.18632/oncotarget.14640 C5355142!5355142 !28099155     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28099155 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (8 ): 13832-13845 Nephropedia Template TP {{tp|p=28099155 |t=2017. Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway |pdf=|usr=}}{{28099155 }} gab.com Text Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28099155 #FOAvip Metformin, as an AMP-activated protein kinase (AMPK) activator, can activate autophagy. A study showed that metformin decreased the risk of hepatocellular carcinoma (HCC) in diabetic patients. However, the detailed mechanism in the metformin-mediated anticancer effect remains an open question. Transcription factor CCAAT/enhancer-binding protein delta (CEBPD) has been suggested to serve as a tumor suppressor and is responsive to multiple anticancer drugs in HCC. In this study, we found that CEBPD and autophagy are involved in metformin-induced cell apoptosis in Huh7 cells. The underlying mechanisms in this process included a reduction in Src-mediated CEBPD protein degradation and an increase in CEBPD-regulated LC3B and ATG3 gene transcription under metformin treatment. We also found that AMPK is involved in metformin-induced CEBPD expression. Combined treatment with metformin and rapamycin can enhance autophagic cell death through the AMPK-dependent and AMPK-independent pathway, respectively. Taken together, we provide a new insight and therapeutic approach by targeting autophagy in the treatment of HCC. Twit Text FOAVip Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28099155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28099155 #FOAvip English Wikipedia <ref>{{Cite pmid|28099155 }}</ref> Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway #MMPMID28099155 Tsai HH ; Lai HY ; Chen YC ; Li CF ; Huang HS ; Liu HS ; Tsai YS ; Wang JM Oncotarget 2017[Feb]; 8 (8 ): 13832-13845 PMID28099155 show ga Metformin, as an AMP-activated protein kinase (AMPK) activator, can activate autophagy. A study showed that metformin decreased the risk of hepatocellular carcinoma (HCC) in diabetic patients. However, the detailed mechanism in the metformin-mediated anticancer effect remains an open question. Transcription factor CCAAT/enhancer-binding protein delta (CEBPD) has been suggested to serve as a tumor suppressor and is responsive to multiple anticancer drugs in HCC. In this study, we found that CEBPD and autophagy are involved in metformin-induced cell apoptosis in Huh7 cells. The underlying mechanisms in this process included a reduction in Src-mediated CEBPD protein degradation and an increase in CEBPD-regulated LC3B and ATG3 gene transcription under metformin treatment. We also found that AMPK is involved in metformin-induced CEBPD expression. Combined treatment with metformin and rapamycin can enhance autophagic cell death through the AMPK-dependent and AMPK-independent pathway, respectively. Taken together, we provide a new insight and therapeutic approach by targeting autophagy in the treatment of HCC. |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Apoptosis/*drug effects [MESH] |Autophagy/*drug effects [MESH] |Blotting, Western [MESH] |CCAAT-Enhancer-Binding Protein-delta/*metabolism [MESH] |Carcinoma, Hepatocellular/*metabolism [MESH] |Cell Line, Tumor [MESH] |Chromatin Immunoprecipitation [MESH] |Flow Cytometry [MESH] |Gene Knockdown Techniques [MESH] |Heterografts [MESH] |Humans [MESH] |Hypoglycemic Agents/pharmacology [MESH] |Liver Neoplasms/*metabolism [MESH] |Male [MESH] |Metformin/*pharmacology [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Microscopy, Fluorescence [MESH]Metformin promotes apoptosis in hepatocellular carcinoma through the (epmc).pdf DeepDyve Pubget Overpricing