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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Dev+Dyn 2017 ; 246 (4): 336-43 Nephropedia Template TP
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Urothelial Generation and Regeneration in Development, Injury, and Cancer #MMPMID28109014
Wang C; Ross WT; Mysorekar IU
Dev Dyn 2017[Apr]; 246 (4): 336-43 PMID28109014show ga
Homeostatic maintenance and repair of the urothelium upon injury are required for a functional bladder in both healthy and disease conditions. Understanding the cellular and molecular mechanisms underlying the urothelial regenerative response is key to designing strategies for tissue repair and ultimately treatments for urologic diseases including urinary tract infections, voiding dysfunction, painful bladder syndrome and bladder cancer. In this article, we review studies on urothelial ontogeny during development and regeneration following various injury modalities. Signaling pathways involved in urothelial regeneration and in urothelial carcinogenesis are also discussed.