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10.18632/oncotarget.13639 http://scihub22266oqcxt.onion/10.18632/oncotarget.13639 C5354934!5354934!27902459     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (3): 5619-28 Nephropedia Template TP {{tp|p=27902459|t=2017. Anti-tumor activity of metformin: from metabolic and epigenetic perspectives |pdf=|usr=}}{{27902459}} gab.com Text Anti-tumor activity of metformin: from metabolic and epigenetic perspectives JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27902459 #FOAvip Metformin has been used to treat type 2 diabetes for over 50 years. Epidemiological, preclinical and clinical studies suggest that metformin treatment reduces cancer incidence in diabetes patients. Due to its potential as an anti-cancer agent and its low cost, metformin has gained intense research interest. Its traditional anti-cancer mechanisms involve both indirect and direct insulin-dependent pathways. Here, we discussed the anti-tumor mechanism of metformin from the aspects of cell metabolism and epigenetic modifications. The effects of metformin on anti-cancer immunity and apoptosis were also described. Understanding these mechanisms will shed lights on application of metformin in clinical trials and development of anti-cancer therapy. Twit Text FOAVip Anti-tumor activity of metformin: from metabolic and epigenetic perspectives ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27902459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27902459 #FOAvip English Wikipedia <ref>{{Cite pmid|27902459}}</ref> Anti-tumor activity of metformin: from metabolic and epigenetic perspectives #MMPMID27902459 Yu X; Mao W; Zhai Y; Tong C; Liu M; Ma L; Yu X; Li S Oncotarget 2017[Jan]; 8 (3): 5619-28 PMID27902459show ga Metformin has been used to treat type 2 diabetes for over 50 years. Epidemiological, preclinical and clinical studies suggest that metformin treatment reduces cancer incidence in diabetes patients. Due to its potential as an anti-cancer agent and its low cost, metformin has gained intense research interest. Its traditional anti-cancer mechanisms involve both indirect and direct insulin-dependent pathways. Here, we discussed the anti-tumor mechanism of metformin from the aspects of cell metabolism and epigenetic modifications. The effects of metformin on anti-cancer immunity and apoptosis were also described. Understanding these mechanisms will shed lights on application of metformin in clinical trials and development of anti-cancer therapy. äAnti-tumor activity of metformin: from metabolic and epigenetic perspe(epmc).pdf DeepDyve Pubget Overpricing