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10.18632/oncotarget.12537

http://scihub22266oqcxt.onion/10.18632/oncotarget.12537
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C5354927!5354927!27732939
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suck abstract from ncbi


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pmid27732939      Oncotarget 2017 ; 8 (3): 5508-22
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  • Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication #MMPMID27732939
  • Wang J; Ye C; Xiong H; Shen Y; Lu Y; Zhou J; Wang L
  • Oncotarget 2017[Jan]; 8 (3): 5508-22 PMID27732939show ga
  • Long non-coding RNAs (lncRNAs), which occupy nearly 98% of genome, have crucial roles in cancer development, including breast cancer. Breast cancer is a disease with high incidence. Despite of recent progress in understanding the molecular mechanisms and combined therapy strategies, the functions and mechanisms of lncRNAs in breast cancer remains unclear. This review presents the currently basic knowledge and research approaches of lncRNAs. We also highlight the latest advances of seven classic lncRNAs and three novel lncRNAs in breast cancer, elucidating their mechanisms and possible therapeutic targets. Additionally, association between lncRNA and specific molecular subtype of breast cancer is reported. Lastly, we briefly delineate the potential roles of lncRNAs in clinical applications as biomarkers and treatment targets.
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