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2017 ; 8
(3
): 5508-5522
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Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism
and clinical implication
#MMPMID27732939
Wang J
; Ye C
; Xiong H
; Shen Y
; Lu Y
; Zhou J
; Wang L
Oncotarget
2017[Jan]; 8
(3
): 5508-5522
PMID27732939
show ga
Long non-coding RNAs (lncRNAs), which occupy nearly 98% of genome, have crucial
roles in cancer development, including breast cancer. Breast cancer is a disease
with high incidence. Despite of recent progress in understanding the molecular
mechanisms and combined therapy strategies, the functions and mechanisms of
lncRNAs in breast cancer remains unclear. This review presents the currently
basic knowledge and research approaches of lncRNAs. We also highlight the latest
advances of seven classic lncRNAs and three novel lncRNAs in breast cancer,
elucidating their mechanisms and possible therapeutic targets. Additionally,
association between lncRNA and specific molecular subtype of breast cancer is
reported. Lastly, we briefly delineate the potential roles of lncRNAs in clinical
applications as biomarkers and treatment targets.