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10.18632/oncotarget.13872 http://scihub22266oqcxt.onion/10.18632/oncotarget.13872 C5354896!5354896!27974684     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (3): 5111-22 Nephropedia Template TP {{tp|p=27974684|t=2017. Macrophage production and activation are dependent on TRIM33 |pdf=|usr=}}{{27974684}} gab.com Text Macrophage production and activation are dependent on TRIM33 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27974684 #FOAvip The tripartite motif (TRIM) family of proteins plays important roles in innate immunity and antimicrobial infection. None of these proteins has been shown to directly regulate transcription of genes in monocyte/macrophage except TRIM33 that we have recently shown to be a macrophage specific transcriptional inhibitor of Ifnb1. Using ChIP-seq analyses, we now report that TRIM33 is bound to two fold more genes in immature than in mature myeloid cell lines. When located near the same genes, TRIM33 is bound to different sequences in the two cell lines suggesting a role of TRIM33 in both immature and mature myeloid cells. Accordingly, expression of TRIM33 in immature myeloid cells is necessary for efficient production of small peritoneal macrophages, monocytes and bone marrow derived macrophage (BMDM) and TRIM33 targets a subset of genes involved in the inflammatory response only in mature myeloid cells. Functionally, this targeting is associated with impaired repression of pathways regulating the late phases of lipopolysaccharide (LPS) activation of BMDM and a high sensitivity to LPS in vivo when the trim33 gene is inactivated in mature myeloid cells. These findings pinpoint TRIM33 as an important transcriptional actor of monocyte/macrophage mediated inflammation. Twit Text FOAVip Macrophage production and activation are dependent on TRIM33 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27974684 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27974684 #FOAvip English Wikipedia <ref>{{Cite pmid|27974684}}</ref> Macrophage production and activation are dependent on TRIM33 #MMPMID27974684 Gallouet AS; Ferri F; Petit V; Parcelier A; Lewandowski D; Gault N; Barroca V; Le Gras S; Soler E; Grosveld F; Davidson I; Romeo PH Oncotarget 2017[Jan]; 8 (3): 5111-22 PMID27974684show ga The tripartite motif (TRIM) family of proteins plays important roles in innate immunity and antimicrobial infection. None of these proteins has been shown to directly regulate transcription of genes in monocyte/macrophage except TRIM33 that we have recently shown to be a macrophage specific transcriptional inhibitor of Ifnb1. Using ChIP-seq analyses, we now report that TRIM33 is bound to two fold more genes in immature than in mature myeloid cell lines. When located near the same genes, TRIM33 is bound to different sequences in the two cell lines suggesting a role of TRIM33 in both immature and mature myeloid cells. Accordingly, expression of TRIM33 in immature myeloid cells is necessary for efficient production of small peritoneal macrophages, monocytes and bone marrow derived macrophage (BMDM) and TRIM33 targets a subset of genes involved in the inflammatory response only in mature myeloid cells. Functionally, this targeting is associated with impaired repression of pathways regulating the late phases of lipopolysaccharide (LPS) activation of BMDM and a high sensitivity to LPS in vivo when the trim33 gene is inactivated in mature myeloid cells. These findings pinpoint TRIM33 as an important transcriptional actor of monocyte/macrophage mediated inflammation. äMacrophage production and activation are dependent on TRIM33 (epmc).pdf DeepDyve Pubget Overpricing