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10.18632/oncotarget.13867 http://scihub22266oqcxt.onion/10.18632/oncotarget.13867 C5354895!5354895 !27974707     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27974707 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (3 ): 5092-5110 Nephropedia Template TP {{tp|p=27974707 |t=2017. Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF-? signaling |pdf=|usr=}}{{27974707 }} gab.com Text Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF- signaling JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27974707 #FOAvip Cancer upregulated gene 2 (CUG2) enhances cell migration and invasion, but the underlying mechanism has not been revealed. Herein, CUG2 decreased the expression of E-cadherin and increased the expression of N-cadherin and vimentin, characteristics of the epithelial-mesenchymal transition (EMT). A CUG2 deletion mutant, lacking interaction with nucleophosmin 1 (NPM1), or suppression of NPM1 reduced wound healing and cell invasion, indicating that CUG2-mediated EMT requires NPM1. CUG2 enhanced activation of Smad2/3 and expression of Snail and Twist, while the CUG2 silence decreased these TGF-? signaling pathways, leading to suppression of EMT. NPM silence also inhibited the CUG2-induced TGF-? signaling. These results suggest that TGF-? signaling is involved in CUG2-induced EMT. Treatment with EW-7197, a novel inhibitor of TGF-? signaling, diminished CUG2-mediated EMT and inhibition of Akt, ERK, JNK, and p38 MAPK, non-canonical TGF-? signaling molecules, also decreased expression of Smad2/3, Snail and Twist, leading to inhibition of EMT. The results confirm that TGF-? signaling is essential for CUG2-mediated EMT. Interestingly, TGF-? enhanced CUG2 expression. We further found that both CUG2-induced TGF-? production and TGF-?-induced CUG2 up-regulation required a physical interaction between Sp1 and Smad2/3 in the CUG2 and TGF-? promoter, as demonstrated by a promoter reporter assay, immunoprecipitation, and ChIP assay. These results indicated close crosstalk between CUG2 and TGF-?. Conversely, suppression of CUG2 or NPM1 did not completely inhibit TGF-?-induced EMT, indicating that the effect of TGF-? on EMT is dominant over the effect of CUG2 on EMT. Collectively, our findings suggest that CUG2 induces the EMT via TGF-? signaling. Twit Text FOAVip Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF- signaling ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27974707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27974707 #FOAvip English Wikipedia <ref>{{Cite pmid|27974707 }}</ref> Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF-? signaling #MMPMID27974707 Kaowinn S ; Kim J ; Lee J ; Shin DH ; Kang CD ; Kim DK ; Lee S ; Kang MK ; Koh SS ; Kim SJ ; Chung YH Oncotarget 2017[Jan]; 8 (3 ): 5092-5110 PMID27974707 show ga Cancer upregulated gene 2 (CUG2) enhances cell migration and invasion, but the underlying mechanism has not been revealed. Herein, CUG2 decreased the expression of E-cadherin and increased the expression of N-cadherin and vimentin, characteristics of the epithelial-mesenchymal transition (EMT). A CUG2 deletion mutant, lacking interaction with nucleophosmin 1 (NPM1), or suppression of NPM1 reduced wound healing and cell invasion, indicating that CUG2-mediated EMT requires NPM1. CUG2 enhanced activation of Smad2/3 and expression of Snail and Twist, while the CUG2 silence decreased these TGF-? signaling pathways, leading to suppression of EMT. NPM silence also inhibited the CUG2-induced TGF-? signaling. These results suggest that TGF-? signaling is involved in CUG2-induced EMT. Treatment with EW-7197, a novel inhibitor of TGF-? signaling, diminished CUG2-mediated EMT and inhibition of Akt, ERK, JNK, and p38 MAPK, non-canonical TGF-? signaling molecules, also decreased expression of Smad2/3, Snail and Twist, leading to inhibition of EMT. The results confirm that TGF-? signaling is essential for CUG2-mediated EMT. Interestingly, TGF-? enhanced CUG2 expression. We further found that both CUG2-induced TGF-? production and TGF-?-induced CUG2 up-regulation required a physical interaction between Sp1 and Smad2/3 in the CUG2 and TGF-? promoter, as demonstrated by a promoter reporter assay, immunoprecipitation, and ChIP assay. These results indicated close crosstalk between CUG2 and TGF-?. Conversely, suppression of CUG2 or NPM1 did not completely inhibit TGF-?-induced EMT, indicating that the effect of TGF-? on EMT is dominant over the effect of CUG2 on EMT. Collectively, our findings suggest that CUG2 induces the EMT via TGF-? signaling. |*Epithelial-Mesenchymal Transition [MESH] |A549 Cells [MESH] |Cadherins/metabolism [MESH] |Cell Line, Tumor [MESH] |Chromosomal Proteins, Non-Histone/*genetics/metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Lung Neoplasms/*genetics/metabolism [MESH] |Nucleophosmin [MESH] |Signal Transduction [MESH] |Transforming Growth Factor beta/*metabolism [MESH]Cancer upregulated gene 2 induces epithelial-mesenchymal transition of(epmc).pdf DeepDyve Pubget Overpricing