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10.18632/oncotarget.13615 http://scihub22266oqcxt.onion/10.18632/oncotarget.13615 C5354880!5354880 !27902486     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27902486 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (3 ): 4914-4921 Nephropedia Template TP {{tp|p=27902486 |t=2017. ED-B fibronectin expression is a marker of epithelial-mesenchymal transition in translational oncology |pdf=|usr=}}{{27902486 }} gab.com Text ED-B fibronectin expression is a marker of epithelial-mesenchymal transition in translational oncology JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27902486 #FOAvip Fibronectin is a component of the extracellular matrix that links collagen fibers to integrins on the cell's surface. The splicing isoforms, containing the ED-B domain, are not expressed in adult tissues but only in tumor stroma or during embryonic development. Fibroblasts and endothelial cells express ED-B fibronectin during angiogenesis. Also cancer cells can synthetize ED-B fibronectin, but its function in tumor growth needs to be further elucidated.We evaluated the expression of ED-B fibronectin in prostate cancer cell lines: PC3 and DU145. Using TGF-?, we induced epithelial to mesenchymal transition in culture and observed an increase of ED-B fibronectin expression. Thereafter, we evaluated the expression of ED-B fibronectin in multipotent mesangiogenic progenitor cells, and in mesenchymal stromal cells. The expression of ED-B fibronectin was much higher in mesenchymal than prostate cancer cells even after the epithelial to mesenchymal transition.Epithelial to mesenchymal transition is a key step for tumor progression contributing to the metastatic spread. Therefore, circulating cancer cells could seed into the metastatic niche taking advantage from the ED-B fibronectin that secrete their own. Twit Text FOAVip ED-B fibronectin expression is a marker of epithelial-mesenchymal transition in translational oncology ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27902486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27902486 #FOAvip English Wikipedia <ref>{{Cite pmid|27902486 }}</ref> ED-B fibronectin expression is a marker of epithelial-mesenchymal transition in translational oncology #MMPMID27902486 Petrini I ; Barachini S ; Carnicelli V ; Galimberti S ; Modeo L ; Boni R ; Sollini M ; Erba PA Oncotarget 2017[Jan]; 8 (3 ): 4914-4921 PMID27902486 show ga Fibronectin is a component of the extracellular matrix that links collagen fibers to integrins on the cell's surface. The splicing isoforms, containing the ED-B domain, are not expressed in adult tissues but only in tumor stroma or during embryonic development. Fibroblasts and endothelial cells express ED-B fibronectin during angiogenesis. Also cancer cells can synthetize ED-B fibronectin, but its function in tumor growth needs to be further elucidated.We evaluated the expression of ED-B fibronectin in prostate cancer cell lines: PC3 and DU145. Using TGF-?, we induced epithelial to mesenchymal transition in culture and observed an increase of ED-B fibronectin expression. Thereafter, we evaluated the expression of ED-B fibronectin in multipotent mesangiogenic progenitor cells, and in mesenchymal stromal cells. The expression of ED-B fibronectin was much higher in mesenchymal than prostate cancer cells even after the epithelial to mesenchymal transition.Epithelial to mesenchymal transition is a key step for tumor progression contributing to the metastatic spread. Therefore, circulating cancer cells could seed into the metastatic niche taking advantage from the ED-B fibronectin that secrete their own. |*Epithelial-Mesenchymal Transition/drug effects [MESH] |*Up-Regulation [MESH] |Biomarkers, Tumor/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cytokines/*metabolism [MESH] |Disease Progression [MESH] |Fibronectins [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Male [MESH] |Mesenchymal Stem Cells/metabolism [MESH] |Neoplasm Metastasis [MESH] |Prostatic Neoplasms/*metabolism [MESH]ED-B fibronectin expression is a marker of epithelial-mesenchymal tran(epmc).pdf DeepDyve Pubget Overpricing