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10.18632/oncotarget.13592 http://scihub22266oqcxt.onion/10.18632/oncotarget.13592 C5354872!5354872!27902475     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (3): 4796-813 Nephropedia Template TP {{tp|p=27902475|t=2017. Osthole protects sepsis-induced acute kidney injury via down-regulating NF-?B signal pathway |pdf=|usr=}}{{27902475}} gab.com Text Osthole protects sepsis-induced acute kidney injury via down-regulating NF- B signal pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27902475 #FOAvip BACKGROUND AND PURPOSE: As a natural coumarin derivative from the Cnidium monnieri(L)Cusson fruit, osthole consists of 7-methoxy-8-isopentenoxy-coumarin. The purpose of this research is to study the mechanism and effect of osthole on sepsis-induced acute kidney injury. EXPERIMENTAL APPROACH: The protective effect of osthole on mouse macrophage RAW 264.7 and HK-2 cells induced by LPS in vitro and on acute kidney injury model induced by sepsis and established by puncture and cecal ligation (CLP) in vivo were tested. KEY RESULTS: Osthole (20, 40 mg·kg?1) group can greatly attenuate the changes of the score and kidney histopathology damage and enhance the survival time of septic mice. After the CLP surgery, degrees of SCr and BUN related to kidney injury were upregulated. The concentrations of SCr and BUN can be greatly reduced by treatment with osthole. Furthermore, osthole could increase bacterial killing activity and phagocytic activities of macrophages impaired after CLP partly and attenuate blood bacterial counts and leukocyte infiltration markedly. Furthermore, osthole can suppress NF-?B signal pathway through the inhibition of the nuclear translocation by regulating phosphorylation of I?B? and IKK? and hinder the production of chemoattractant (MCP-1 and IL-8) and proinflammatory cytokines (TNF-?, IL-1? and IL-6). CONCLUSION AND IMPLICATIONS: Mainly because of its immunomodulatory properties and anti-inflammatory activity, which might be closely associated with suppression of the stimulation of the NF-?B signal pathway, osthole has protective effect on sepsis-induced kidney injury. It can be seen from such evidence that osthole can be potentially applied in the treatment of acute kidney injury. Twit Text FOAVip Osthole protects sepsis-induced acute kidney injury via down-regulating NF- B signal pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27902475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27902475 #FOAvip English Wikipedia <ref>{{Cite pmid|27902475}}</ref> Osthole protects sepsis-induced acute kidney injury via down-regulating NF-?B signal pathway #MMPMID27902475 Yu C; Li P; Qi D; Wang L; Qu Hl; Zhang Yj; Wang Xk; Fan HY Oncotarget 2017[Jan]; 8 (3): 4796-813 PMID27902475show ga BACKGROUND AND PURPOSE: As a natural coumarin derivative from the Cnidium monnieri(L)Cusson fruit, osthole consists of 7-methoxy-8-isopentenoxy-coumarin. The purpose of this research is to study the mechanism and effect of osthole on sepsis-induced acute kidney injury. EXPERIMENTAL APPROACH: The protective effect of osthole on mouse macrophage RAW 264.7 and HK-2 cells induced by LPS in vitro and on acute kidney injury model induced by sepsis and established by puncture and cecal ligation (CLP) in vivo were tested. KEY RESULTS: Osthole (20, 40 mg·kg?1) group can greatly attenuate the changes of the score and kidney histopathology damage and enhance the survival time of septic mice. After the CLP surgery, degrees of SCr and BUN related to kidney injury were upregulated. The concentrations of SCr and BUN can be greatly reduced by treatment with osthole. Furthermore, osthole could increase bacterial killing activity and phagocytic activities of macrophages impaired after CLP partly and attenuate blood bacterial counts and leukocyte infiltration markedly. Furthermore, osthole can suppress NF-?B signal pathway through the inhibition of the nuclear translocation by regulating phosphorylation of I?B? and IKK? and hinder the production of chemoattractant (MCP-1 and IL-8) and proinflammatory cytokines (TNF-?, IL-1? and IL-6). CONCLUSION AND IMPLICATIONS: Mainly because of its immunomodulatory properties and anti-inflammatory activity, which might be closely associated with suppression of the stimulation of the NF-?B signal pathway, osthole has protective effect on sepsis-induced kidney injury. It can be seen from such evidence that osthole can be potentially applied in the treatment of acute kidney injury. äOsthole protects sepsis-induced acute kidney injury via down-regulatin(epmc).pdf DeepDyve Pubget Overpricing