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2017 ; 8
(3
): 4629-4641
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
MicroRNA-182 drives colonization and macroscopic metastasis via targeting its
suppressor SNAI1 in breast cancer
#MMPMID27894095
Zhan Y
; Li X
; Liang X
; Li L
; Cao B
; Wang B
; Ma J
; Ding F
; Wang X
; Pang D
; Liu Z
Oncotarget
2017[Jan]; 8
(3
): 4629-4641
PMID27894095
show ga
Metastasis is a multi-step process. Tumor cells occur epithelial-mesenchymal
transition (EMT) to start metastasis, then, they need to undergo a reverse
progression of EMT, mesenchymal-epithelial transition (MET), to colonize and form
macrometastases at distant organs to complete the whole process of metastasis.
Although microRNAs (miRNAs) functions in EMT process are well established, their
influence on colonization and macrometastases formation remains unclear. Here, we
established an EMT model in MCF-10A cells with SNAI1 overexpression, and
characterized some EMT-related microRNAs. We identified that miR-182, which was
directly suppressed by SNAI1, could enable an epithelial-like state in breast
cancer cells in vitro, and enhance colonization and macrometastases in vivo.
Subsequent studies showed that miR-182 exerted its function through targeting its
suppressor SNAI1. Moreover, higher expression level of miR-182 was detected in
metastatic lymph nodes, compared with paired primary tumor tissues. In addition,
the expression level of miR-182 was negatively correlated with that of SNAI1 in
these clinical specimens. Taking together, our findings describe the role of
miR-182 in colonization and macrometastases in breast cancer for the first time,
and provide a promise for diagnosis or therapy of breast cancer metastasis.
|Animals
[MESH]
|Breast Neoplasms/*genetics/*pathology
[MESH]
|Cell Line, Tumor
[MESH]
|Epithelial-Mesenchymal Transition
[MESH]
|Female
[MESH]
|Gene Expression Profiling
[MESH]
|Gene Expression Regulation, Neoplastic
[MESH]
|Gene Regulatory Networks
[MESH]
|Humans
[MESH]
|MCF-7 Cells
[MESH]
|Mice
[MESH]
|MicroRNAs/*genetics
[MESH]
|Neoplasm Metastasis
[MESH]
|Neoplasm Transplantation
[MESH]
|Snail Family Transcription Factors/*genetics
[MESH]
free
free
free
