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10.18632/oncotarget.9830 http://scihub22266oqcxt.onion/10.18632/oncotarget.9830 C5354798!5354798!27270652     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (3): 3826-39 Nephropedia Template TP {{tp|p=27270652|t=2017. Loss of TGF? signaling promotes colon cancer progression and tumor-associated inflammation |pdf=|usr=}}{{27270652}} gab.com Text Loss of TGF signaling promotes colon cancer progression and tumor-associated inflammation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27270652 #FOAvip TGF? has both tumor suppressive and tumor promoting effects in colon cancer. Also, TGF? can affect the extent and composition of inflammatory cells present in tumors, contextually promoting and inhibiting inflammation. While colon tumors display intratumoral inflammation, the contributions of TGF? to this process are poorly understood. In human patients, we found that epithelial loss of TGF? signaling was associated with increased inflammatory burden; yet overexpression of TGF? was also associated with increased inflammation. These findings were recapitulated in mutant APC models of murine tumorigenesis, where epithelial truncation of TGFBR2 led to lethal inflammatory disease and invasive colon cancer, mediated by IL8 and TGF?1. Interestingly, mutant APC mice with global suppression of TGF? signals displayed an intermediate phenotype, presenting with an overall increase in IL8-mediated inflammation and accelerated tumor formation, yet with a longer latency to the onset of disease observed in mice with epithelial TGFBR-deficiency. These results suggest that the loss of TGF? signaling, particularly in colon epithelial cells, elicits a strong inflammatory response and promotes tumor progression. This implies that treating colon cancer patients with TGF? inhibitors may result in a worse outcome by enhancing inflammatory responses. Twit Text FOAVip Loss of TGF signaling promotes colon cancer progression and tumor-associated inflammation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27270652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27270652 #FOAvip English Wikipedia <ref>{{Cite pmid|27270652}}</ref> Loss of TGF? signaling promotes colon cancer progression and tumor-associated inflammation #MMPMID27270652 Principe DR; DeCant B; Staudacher J; Vitello D; Mangan RJ; Wayne EA; Mascariņas E; Diaz AM; Bauer J; McKinney RD; Khazaie K; Pasche B; Dawson DW; Munshi HG; Grippo PJ; Jung B Oncotarget 2017[Jan]; 8 (3): 3826-39 PMID27270652show ga TGF? has both tumor suppressive and tumor promoting effects in colon cancer. Also, TGF? can affect the extent and composition of inflammatory cells present in tumors, contextually promoting and inhibiting inflammation. While colon tumors display intratumoral inflammation, the contributions of TGF? to this process are poorly understood. In human patients, we found that epithelial loss of TGF? signaling was associated with increased inflammatory burden; yet overexpression of TGF? was also associated with increased inflammation. These findings were recapitulated in mutant APC models of murine tumorigenesis, where epithelial truncation of TGFBR2 led to lethal inflammatory disease and invasive colon cancer, mediated by IL8 and TGF?1. Interestingly, mutant APC mice with global suppression of TGF? signals displayed an intermediate phenotype, presenting with an overall increase in IL8-mediated inflammation and accelerated tumor formation, yet with a longer latency to the onset of disease observed in mice with epithelial TGFBR-deficiency. These results suggest that the loss of TGF? signaling, particularly in colon epithelial cells, elicits a strong inflammatory response and promotes tumor progression. This implies that treating colon cancer patients with TGF? inhibitors may result in a worse outcome by enhancing inflammatory responses. äLoss of TGF? signaling promotes colon cancer progression and tumor-ass(epmc).pdf DeepDyve Pubget Overpricing