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2017 ; 8
(6
): 10692-10702
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A systematic review and meta-analysis: Does hepatitis C virus infection
predispose to the development of chronic kidney disease?
#MMPMID27793016
Li M
; Wang P
; Yang C
; Jiang W
; Wei X
; Mu X
; Li X
; Mi J
; Tian G
Oncotarget
2017[Feb]; 8
(6
): 10692-10702
PMID27793016
show ga
We aimed to meta-analytically assess the predisposition of hepatitis C virus
(HCV) infection to the occurrence and severity of chronic kidney disease (CKD).
Two authors independently searched articles and abstracted information. Odds
ratio (OR) or hazard ratio (HR) along with 95% confidence interval (CI) was
converged separately in 12 longitudinal (1,972,044 subjects) and 15
cross-sectional (937,607 subjects) studies. Overall effect estimate was
remarkably significant in longitudinal studies (HR, 95% CI, P: 1.45, 1.23-1.71, <
0.001), in contrast to that in cross-sectional studies (OR, 95% CI, P: 1.25,
0.90-1.73, 0.188), with obvious heterogeneity (I2 > 95%). HCV infection was also
associated with an 1.54-fold (95% CI, P: 1.27-1.87, < 0.001) increased risk of
having prevalent proteinuria. In longitudinal studies with estimated glomerular
filtration rate (eGFR) < 60, < 30 and < 15 ml/min/1.73m2, the corresponding HR
was 1.39 (95% CI, P: 1.14-1.69, 0.001), 1.79 (0.91-3.51, 0.091) and 2.30
(1.26-4.19, 0.007). Further grouping the longitudinal studies by median follow-up
time at 5 years revealed that the effect estimate was reinforced in long-term
studies (HR, 95% CI, P: 1.86, 1.19-2.89, 0.006; I2=98.1%) relative to that in
short-term studies (1.21, 1.03-1.43, 0.024; 92.0%). In conclusion, our findings
demonstrate the significant risk of experiencing incident CKD after HCV
infection, with the lower eGFR and longer HCV exposure time entailing a greater
risk.