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2017 ; 8
(6
): 10628-10636
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Effects of continuous renal replacement therapy on serum cytokines, neutrophil
gelatinase-associated lipocalin, and prognosis in patients with severe acute
kidney injury after cardiac surgery
#MMPMID27833089
Wang HJ
; Wang P
; Li N
; Wan C
; Jiang CM
; He JS
; Wang DJ
; Zhang M
; Sun LY
Oncotarget
2017[Feb]; 8
(6
): 10628-10636
PMID27833089
show ga
The aim of our study was to evaluate the effect of continuous renal replacement
therapy (CRRT) on serum cytokines, neutrophil gelatinase-associated lipocalin
(NGAL), and prognosis in patients with severe acute kidney injury (AKI) following
cardiac surgery. A total number of 153 patients with severe AKI following cardiac
surgery were treated with CRRT. They were divided into the survival and
non-survival groups. Clinical data from these two groups before and after CRRT
were recorded and analyzed. It was found that the number of impaired organs, MODS
and APACHE II scores were significantly higher in the non-survival group than
those in the survival group before CRRT. After CRRT, MODS and APACHE II scores
decreased significantly. The post-CRRT levels of serum TNF-? and IL-6 were
significantly decreased. After CRRT, serum NGAL decreased in the two groups, but
the levels were higher in the non-survival group than those in the survival
group. MODS and APACHE II scores could be used to evaluate the severity of AKI in
patients after cardiac surgery. CRRT is an effective treatment for these patients
and high levels of TNF-?, IL-6, and NGAL are associated with a poor prognosis in
these patients.