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A short-term intervention with selenium affects expression of genes implicated in
the epithelial-to-mesenchymal transition in the prostate
#MMPMID28076331
Kok DE
; Kiemeney LA
; Verhaegh GW
; Schalken JA
; van Lin EN
; Sedelaar JP
; Witjes JA
; Hulsbergen-van de Kaa CA
; van 't Veer P
; Kampman E
; Afman LA
Oncotarget
2017[Feb]; 8
(6
): 10565-10579
PMID28076331
show ga
In parallel with the inconsistency in observational studies and chemoprevention
trials, the mechanisms by which selenium affects prostate cancer risk have not
been elucidated. We conducted a randomized, placebo-controlled trial to examine
the effects of a short-term intervention with selenium on gene expression in
non-malignant prostate tissue. Twenty-three men received 300 µg selenium per day
in the form of selenized yeast (n=12) or a placebo (n=11) during 5 weeks.
Prostate biopsies collected from the transition zone before and after
intervention were analysed for 15 participants (n=8 selenium, n=7 placebo).
Pathway analyses revealed that the intervention with selenium was associated with
down-regulated expression of genes involved in cellular migration, invasion,
remodeling and immune responses. Specifically, expression of well-established
epithelial markers, such as E-cadherin and epithelial cell adhesion molecule
EPCAM, was up-regulated, while the mesenchymal markers vimentin and fibronectin
were down-regulated after intervention with selenium. This implies an inhibitory
effect of selenium on the epithelial-to-mesenchymal transition (EMT). Moreover,
selenium was associated with down-regulated expression of genes involved in wound
healing and inflammation; processes which are both related to EMT. In conclusion,
our explorative data showed that selenium affected expression of genes implicated
in EMT in the transition zone of the prostate.
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