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2017 ; 8
(6
): 10238-10254
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The biological properties of different Epstein-Barr virus strains explain their
association with various types of cancers
#MMPMID28052012
Tsai MH
; Lin X
; Shumilov A
; Bernhardt K
; Feederle R
; Poirey R
; Kopp-Schneider A
; Pereira B
; Almeida R
; Delecluse HJ
Oncotarget
2017[Feb]; 8
(6
): 10238-10254
PMID28052012
show ga
The Epstein-Barr virus (EBV) is etiologically associated with the development of
multiple types of tumors, but it is unclear whether this diversity is due to
infection with different EBV strains. We report a comparative characterization of
SNU719, GP202, and YCCEL1, three EBV strains that were isolated from gastric
carcinomas, M81, a virus isolated in a nasopharyngeal carcinoma and several
well-characterized laboratory type A strains. We found that B95-8, Akata and
GP202 induced cell growth more efficiently than YCCEL1, SNU719 and M81 and this
correlated positively with the expression levels of the viral BHRF1 miRNAs. In
infected B cells, all strains except Akata and B95-8 induced lytic replication, a
risk factor for carcinoma development, although less efficiently than M81. The
panel of viruses induced tumors in immunocompromised mice with variable speed and
efficacy that did not strictly mirror their in vitro characteristics, suggesting
that additional parameters play an important role. We found that YCCEL1 and M81
infected primary epithelial cells, gastric carcinoma cells and gastric spheroids
more efficiently than Akata or B95-8. Reciprocally, Akata and B95-8 had a
stronger tropism for B cells than YCCEL1 or M81. These data suggest that
different EBV strains will induce the development of lymphoid tumors with
variable efficacy in immunocompromised patients and that there is a parallel
between the cell tropism of the viral strains and the lineage of the tumors they
induce. Thus, EBV strains can be endowed with properties that will influence
their transforming abilities and the type of tumor they induce.
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