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Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like
Behaviors through Reduced Secretion of FGF2
#MMPMID26606998
Birey F
; Kloc M
; Chavali M
; Hussein I
; Wilson M
; Christoffel DJ
; Chen T
; Frohman MA
; Robinson JK
; Russo SJ
; Maffei A
; Aguirre A
Neuron
2015[Dec]; 88
(5
): 941-956
PMID26606998
show ga
NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active
pool of cells in the central nervous system (CNS). In addition to serving as
progenitors of myelinating oligodendrocytes, NG2 glia might also fulfill
physiological roles in CNS homeostasis, although the mechanistic nature of such
roles remains unclear. Here, we report that ablation of NG2 glia in the
prefrontal cortex (PFC) of the adult brain causes deficits in excitatory
glutamatergic neurotransmission and astrocytic extracellular glutamate uptake and
induces depressive-like behaviors in mice. We show in parallel that chronic
social stress causes NG2 glia density to decrease in areas critical to Major
Depressive Disorder (MDD) pathophysiology at the time of symptom emergence in
stress-susceptible mice. Finally, we demonstrate that loss of NG2 glial secretion
of fibroblast growth factor 2 (FGF2) suffices to induce the same behavioral
deficits. Our findings outline a pathway and role for NG2 glia in CNS homeostasis
and mood disorders.
|Amino Acid Transport System X-AG/genetics/metabolism
[MESH]
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