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OCF can repress tumor metastasis by inhibiting epithelial-mesenchymal transition
involved in PTEN/PI3K/AKT pathway in lung cancer cells
#MMPMID28301605
Yang Y
; Qiu S
; Qian L
; Tian Y
; Chen Y
; Bi L
; Chen W
PLoS One
2017[]; 12
(3
): e0174021
PMID28301605
show ga
A component formula with definite compositions provides a new approach to treat
various diseases. Salvia miltiorrhiza and Panax ginseng are widely used in China
because of their antitumor properties. In the previous study, the optimizing
component formula (OCF), prepared with salvianolic acids, ginsenosides, and
ginseng polysaccharides (5, 10, and 5 mg·L-1, respectively) extracted from S.
miltiorrhiza and P. ginseng on the basis of IC50 in lung cancer A549 cells and
damage minimization on human bronchial epithelial cells in vitro. Currently, we
also have demonstrated the inhibitory effect of OCF on A549 cell migration and
invasion in vitro. According to Lewis lung cancer cells (LLC) allograft in
C57BL/6 mice and A549 xenograft in nude mice experiment, we found that the
anti-tumor and anti-metastasis effects of OCF treatment were related to the
inhibition of epithelial-mesenchymal transition (EMT). Further studies showed
that the inhibitory effect of OCF on EMT was associated with the PTEN/PI3K/AKT
pathway. Therefore, all studies revealed that OCF could prevent cancer
progression and tumor metastasis by inhibiting EMT involved PTEN/PI3K/AKT
signaling pathway in lung cancer cells.
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