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10.1371/journal.pone.0172556 http://scihub22266oqcxt.onion/10.1371/journal.pone.0172556 C5354370!5354370!28301490     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2017 ; 12 (3): ä Nephropedia Template TP {{tp|p=28301490|t=2017. A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery |pdf=|usr=}}{{28301490}} gab.com Text A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28301490 #FOAvip Purpose/Relevance: Fibrosis and hence capsule formation around the glaucoma implants are the main reasons for glaucoma implant failure. To address these issues, we designed a microfluidic meshwork and tested its biocompatibility in a rabbit eye model. The amount of fibrosis elicited by the microfluidic meshwork was compared to the amount elicited by the plate of conventional glaucoma drainage device. Methods: Six eyes from 3 New Zealand albino rabbits were randomized to receive either the novel microfluidic meshwork or a plate of Ahmed glaucoma valve model PF7 (AGV PF7). The flexible microfluidic implant was made from negative photoresist SU-8 by using micro-fabrication techniques. The overall size of the meshwork was 7 mm × 7 mm with a grid period of 100 ?m. Both implants were placed in the subtenon space at the supratemporal quadrant in a standard fashion. There was no communication between the implants and the anterior chamber via a tube. All animal eyes were examined for signs of infection and implant erosion on days 1, 3, 7, and 14 and then monthly. Exenterations were performed in which the entire orbital contents were removed at 3 months. Histology slides of the implant and the surrounding tissues were prepared and stained with hematoxylin-eosin. Thickness of the fibrous capsules beneath the implants were measured and compared with paired student?s t-test between the two groups. Results: The gross histological sections showed that nearly no capsule formed around the microfluidic meshwork in contrast to the thick capsule formed around the plate of AGV PF7. Thickness of the fibrotic capsules beneath the AGV PF7 plate from the 3 rabbit eyes was 90?m, 82?m, and 95 ?m, respectively. The thickness at the bottom of fibrotic capsules around the new microfluidic implant were 1?m, 2?m, and 1?m, respectively. The difference in thickness of capsule between the two groups was significant (P= 0.002). No complications were noticed in the 6 eyes, and both implants were tolerated well by all rabbits. Conclusion: The microfluidic meshwork elicited minimal fibrosis and capsule formation after 3-months implantation in a rabbit model. This provides promising evidence to aid in future development of a new glaucoma drainage implant that will elicit minimal scar formation and provide better long-term surgical outcomes. Twit Text FOAVip A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28301490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28301490 #FOAvip English Wikipedia <ref>{{Cite pmid|28301490}}</ref> A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery #MMPMID28301490 Amoozgar B; Wei X; Hui Lee J; Bloomer M; Zhao Z; Coh P; He F; Luan L; Xie C; Han Y PLoS One 2017[]; 12 (3): ä PMID28301490show ga Purpose/Relevance: Fibrosis and hence capsule formation around the glaucoma implants are the main reasons for glaucoma implant failure. To address these issues, we designed a microfluidic meshwork and tested its biocompatibility in a rabbit eye model. The amount of fibrosis elicited by the microfluidic meshwork was compared to the amount elicited by the plate of conventional glaucoma drainage device. Methods: Six eyes from 3 New Zealand albino rabbits were randomized to receive either the novel microfluidic meshwork or a plate of Ahmed glaucoma valve model PF7 (AGV PF7). The flexible microfluidic implant was made from negative photoresist SU-8 by using micro-fabrication techniques. The overall size of the meshwork was 7 mm × 7 mm with a grid period of 100 ?m. Both implants were placed in the subtenon space at the supratemporal quadrant in a standard fashion. There was no communication between the implants and the anterior chamber via a tube. All animal eyes were examined for signs of infection and implant erosion on days 1, 3, 7, and 14 and then monthly. Exenterations were performed in which the entire orbital contents were removed at 3 months. Histology slides of the implant and the surrounding tissues were prepared and stained with hematoxylin-eosin. Thickness of the fibrous capsules beneath the implants were measured and compared with paired student?s t-test between the two groups. Results: The gross histological sections showed that nearly no capsule formed around the microfluidic meshwork in contrast to the thick capsule formed around the plate of AGV PF7. Thickness of the fibrotic capsules beneath the AGV PF7 plate from the 3 rabbit eyes was 90?m, 82?m, and 95 ?m, respectively. The thickness at the bottom of fibrotic capsules around the new microfluidic implant were 1?m, 2?m, and 1?m, respectively. The difference in thickness of capsule between the two groups was significant (P= 0.002). No complications were noticed in the 6 eyes, and both implants were tolerated well by all rabbits. Conclusion: The microfluidic meshwork elicited minimal fibrosis and capsule formation after 3-months implantation in a rabbit model. This provides promising evidence to aid in future development of a new glaucoma drainage implant that will elicit minimal scar formation and provide better long-term surgical outcomes. äA novel flexible microfluidic meshwork to reduce fibrosis in glaucoma (epmc).pdf DeepDyve Pubget Overpricing