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10.1080/21505594.2016.1196301

http://scihub22266oqcxt.onion/10.1080/21505594.2016.1196301
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suck abstract from ncbi


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pmid27268469
      Virulence 2017 ; 8 (2 ): 138-142
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  • Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi #MMPMID27268469
  • Wiederhold NP ; Patterson TF ; Srinivasan A ; Chaturvedi AK ; Fothergill AW ; Wormley FL ; Ramasubramanian AK ; Lopez-Ribot JL
  • Virulence 2017[Feb]; 8 (2 ): 138-142 PMID27268469 show ga
  • Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.
  • |*Drug Repositioning [MESH]
  • |Antifungal Agents/*pharmacology [MESH]
  • |Antirheumatic Agents/*pharmacology [MESH]
  • |Aspergillus fumigatus/drug effects [MESH]
  • |Auranofin/*pharmacology [MESH]
  • |Candida albicans/*drug effects [MESH]
  • |Candidiasis/microbiology [MESH]
  • |Fungi/drug effects [MESH]
  • |Humans [MESH]


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