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10.1186/s12872-017-0511-8 http://scihub22266oqcxt.onion/10.1186/s12872-017-0511-8 C5353890!5353890 !28298191     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28298191 &cmd=llinks): Failed to open stream: HTTP request failed! 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Bleeding events associated with a low dose (110 mg) versus a high dose (150 mg) of dabigatran in patients treated for atrial fibrillation: a systematic review and meta-analysis |pdf=|usr=}}{{28298191 }} gab.com Text Bleeding events associated with a low dose (110 mg) versus a high dose (150 mg) of dabigatran in patients treated for atrial fibrillation: a systematic review and meta-analysis JO: BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=28298191 #FOAvip BACKGROUND: The newer oral anticoagulant dabigatran is considered to be more beneficial in patients with non-valvular Atrial Fibrillation (AF) when compared to warfarin. However, because bleeding events which are associated with a low dose (110 mg) versus a high dose (150 mg) of dabigatran have seldom been compared, we aimed to systematically solve this important issue through this meta-analysis. METHODS: English publications comparing 110 mg with 150 mg dabigatran in patients who were treated for AF were electronically searched through medical databases. Bleeding outcomes were the major clinical endpoints to be assessed. Odds Ratios (OR) and 95% Confidence Intervals (CIs) for each subgroup were calculated and the main analysis was carried out by the latest version of the RevMan 5.3 software. RESULTS: Twenty-nine thousand two hundred and sixty-four (29,264) patients were included in this meta-analysis. Fifteen thousand eight hundred and forty-eight (15,848) patients were treated with 110 mg dabigatran whereas 13,416 patients were treated with 150 mg dabigatran. 110 mg dabigatran was associated with a significantly lower rate of minor bleeding (OR: 1.19, 95% CI: 1.10-1.27; P?<?0.00001). A similar rate of fatal and major bleeding was observed with both dosages (OR: 1.12, 95% CI: 0.69-1.82; P?=?0.65) and (OR: 1.09, 95% CI: 0.86-1.37; P?=?0.49) respectively. However, ischemic stroke insignificantly favored a higher dose of dabigatran, (OR: 0.77, 95% CI: 0.51-1.16; P?=?0.21). In addition, this analysis showed mortality to significantly favor 150 mg of dabigatran (OR: 0.41, 95% CI: 0.34-0.50; P?<?0.00001). CONCLUSION: No significant differences in major and fatal bleedings were observed with 110 mg versus 150 mg dabigatran. However, 110 mg dabigatran was associated with a significantly lower risk of minor bleeding. These results should further be confirmed in future trials. Twit Text FOAVip Bleeding events associated with a low dose (110 mg) versus a high dose (150 mg) of dabigatran in patients treated for atrial fibrillation: a systematic review and meta-analysis ????BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=28298191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28298191 #FOAvip English Wikipedia <ref>{{Cite pmid|28298191 }}</ref> Bleeding events associated with a low dose (110 mg) versus a high dose (150 mg) of dabigatran in patients treated for atrial fibrillation: a systematic review and meta-analysis #MMPMID28298191 Bundhun PK ; Chaudhary N ; Yuan J BMC Cardiovasc Disord 2017[Mar]; 17 (1 ): 83 PMID28298191 show ga BACKGROUND: The newer oral anticoagulant dabigatran is considered to be more beneficial in patients with non-valvular Atrial Fibrillation (AF) when compared to warfarin. However, because bleeding events which are associated with a low dose (110 mg) versus a high dose (150 mg) of dabigatran have seldom been compared, we aimed to systematically solve this important issue through this meta-analysis. METHODS: English publications comparing 110 mg with 150 mg dabigatran in patients who were treated for AF were electronically searched through medical databases. Bleeding outcomes were the major clinical endpoints to be assessed. Odds Ratios (OR) and 95% Confidence Intervals (CIs) for each subgroup were calculated and the main analysis was carried out by the latest version of the RevMan 5.3 software. RESULTS: Twenty-nine thousand two hundred and sixty-four (29,264) patients were included in this meta-analysis. Fifteen thousand eight hundred and forty-eight (15,848) patients were treated with 110 mg dabigatran whereas 13,416 patients were treated with 150 mg dabigatran. 110 mg dabigatran was associated with a significantly lower rate of minor bleeding (OR: 1.19, 95% CI: 1.10-1.27; P? |Anticoagulants/administration & dosage/adverse effects [MESH] |Antithrombins [MESH] |Atrial Fibrillation/complications/*therapy [MESH] |Dabigatran/administration & dosage/*adverse effects [MESH] |Dose-Response Relationship, Drug [MESH] |Global Health [MESH] |Hemorrhage/*chemically induced/epidemiology [MESH] |Humans [MESH] |Incidence [MESH] |Stroke/*prevention & control [MESH]Bleeding events associated with a low dose (110 mg) versus a high dose(epmc).pdf DeepDyve Pubget Overpricing