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10.1038/srep44324 http://scihub22266oqcxt.onion/10.1038/srep44324 C5353757!5353757 !28295017     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28295017 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 44324 Nephropedia Template TP {{tp|p=28295017 |t=2017. Antimicrobial peptide gramicidin S is accumulated in granules of producer cells for storage of bacterial phosphagens |pdf=|usr=}}{{28295017 }} gab.com Text Antimicrobial peptide gramicidin S is accumulated in granules of producer cells for storage of bacterial phosphagens JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28295017 #FOAvip Many antimicrobial peptides are synthesized non-ribosomally in bacteria, but little is known about their subcellular route of biosynthesis, their mode of intracellular accumulation, or their role in the physiology of the producer cells. Here, we present a comprehensive view on the biosynthesis of gramicidin S (GS) in Aneurinibacillus migulanus, having observed a peripheral membrane localization of its synthetases. The peptide gets accumulated in nano-globules, which mature by fusion into larger granules and end up within vacuolar structures. These granules serve as energy storage devices, as they contain GS molecules that are non-covalently attached to alkyl phosphates and protect them from dephosphorylation and premature release of energy. This finding of a fundamentally new type of high-energy phosphate storage mechanism can explain the curious role of GS biosynthesis in the physiology of the bacterial producer cells. The unknown role of the GrsT protein, which is part of the non-ribosomal GS synthetase operon, can thus be assumed to be responsible for the biosynthesis of alkyl phosphates. GS binding to alkyl phosphates may suggest its general affinity to phosphagens such as ATP and GTP, which can represent the important intracellular targets in pathogenic bacteria. Twit Text FOAVip Antimicrobial peptide gramicidin S is accumulated in granules of producer cells for storage of bacterial phosphagens ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28295017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28295017 #FOAvip English Wikipedia <ref>{{Cite pmid|28295017 }}</ref> Antimicrobial peptide gramicidin S is accumulated in granules of producer cells for storage of bacterial phosphagens #MMPMID28295017 Berditsch M ; Trapp M ; Afonin S ; Weber C ; Misiewicz J ; Turkson J ; Ulrich AS Sci Rep 2017[Mar]; 7 (ä): 44324 PMID28295017 show ga Many antimicrobial peptides are synthesized non-ribosomally in bacteria, but little is known about their subcellular route of biosynthesis, their mode of intracellular accumulation, or their role in the physiology of the producer cells. Here, we present a comprehensive view on the biosynthesis of gramicidin S (GS) in Aneurinibacillus migulanus, having observed a peripheral membrane localization of its synthetases. The peptide gets accumulated in nano-globules, which mature by fusion into larger granules and end up within vacuolar structures. These granules serve as energy storage devices, as they contain GS molecules that are non-covalently attached to alkyl phosphates and protect them from dephosphorylation and premature release of energy. This finding of a fundamentally new type of high-energy phosphate storage mechanism can explain the curious role of GS biosynthesis in the physiology of the bacterial producer cells. The unknown role of the GrsT protein, which is part of the non-ribosomal GS synthetase operon, can thus be assumed to be responsible for the biosynthesis of alkyl phosphates. GS binding to alkyl phosphates may suggest its general affinity to phosphagens such as ATP and GTP, which can represent the important intracellular targets in pathogenic bacteria. |*Gene Expression Regulation, Bacterial [MESH] |Adenosine Triphosphate/biosynthesis [MESH] |Amino Acid Isomerases/genetics/metabolism [MESH] |Anti-Bacterial Agents/*biosynthesis [MESH] |Bacillales/genetics/*metabolism/ultrastructure [MESH] |Bacterial Proteins/*genetics/metabolism [MESH] |Cell Membrane/metabolism/ultrastructure [MESH] |Cytoplasmic Granules/*metabolism/ultrastructure [MESH] |Gramicidin/*biosynthesis [MESH] |Guanosine Triphosphate/biosynthesis [MESH] |Isoenzymes/genetics/metabolism [MESH] |Multienzyme Complexes/genetics/metabolism [MESH] |Operon [MESH] |Peptide Synthases/genetics/metabolism [MESH] |Protein Binding [MESH]Antimicrobial peptide gramicidin S is accumulated in granules of produ(epmc).pdf DeepDyve Pubget Overpricing