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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep44584 http://scihub22266oqcxt.onion/10.1038/srep44584 C5353686!5353686 !28294194     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28294194 &cmd=llinks): Failed to open stream: HTTP request failed! 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Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7 |pdf=|usr=}}{{28294194 }} gab.com Text Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28294194 #FOAvip Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective proprieties of PDE5is on renal hemodynamics and the molecular mechanisms involved. PDE5i treatment prevented the development of DN-related hypertension (P?<?0.001), the increase of urine albumin creatinine ratio (P?<?0.01), the fall in glomerular filtration rate (P?<?0.001), and improved renal resistive index (P?<?0.001) and kidney microcirculation. Moreover PDE5i attenuated the rise of nephropathy biomarkers, soluble urokinase-type plasminogen activator receptor, suPAR and neutrophil gelatinase-associated lipocalin, NGAL. In treated animals, blood vessel perfusion was improved and vascular leakage reduced, suggesting preserved renal endothelium integrity, as confirmed by higher capillary density, number of CD31(+) cells and pericyte coverage. Analysis of the mechanisms involved revealed the induction of bone morphogenetic protein-7 (BMP7) expression, a critical regulator of angiogenesis and kidney homeostasis, through a PDE5i-dependent downregulation of miR-22. In conclusion PDE5i slows the progression of DN in mice, improving hemodynamic parameters and vessel integrity. Regulation of miR-22/BMP7, an unknown mechanism of PDE5is in nephrovascular protection, might represent a novel therapeutic option for treatment of diabetic complications. Twit Text FOAVip Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28294194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28294194 #FOAvip English Wikipedia <ref>{{Cite pmid|28294194 }}</ref> Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7 #MMPMID28294194 Pofi R ; Fiore D ; De Gaetano R ; Panio G ; Gianfrilli D ; Pozza C ; Barbagallo F ; Xiang YK ; Giannakakis K ; Morano S ; Lenzi A ; Naro F ; Isidori AM ; Venneri MA Sci Rep 2017[Mar]; 7 (ä): 44584 PMID28294194 show ga Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective proprieties of PDE5is on renal hemodynamics and the molecular mechanisms involved. PDE5i treatment prevented the development of DN-related hypertension (P? |Albumins/metabolism [MESH] |Animals [MESH] |Biomarkers/blood [MESH] |Bone Morphogenetic Protein 7/*genetics [MESH] |Creatinine/urine [MESH] |Cyclic Nucleotide Phosphodiesterases, Type 5/drug effects/*genetics [MESH] |Diabetic Nephropathies/complications/*genetics/pathology [MESH] |Gene Expression Regulation/drug effects [MESH] |Glomerular Filtration Rate/drug effects [MESH] |Hemodynamics/drug effects [MESH] |Humans [MESH] |Hypertension/complications/drug therapy/genetics/pathology [MESH] |Kidney Failure, Chronic/drug therapy/genetics/pathology [MESH] |Kidney/drug effects/pathology [MESH] |Male [MESH] |Mice [MESH] |MicroRNAs/*genetics [MESH] |Phosphodiesterase 5 Inhibitors/*administration & dosage [MESH]Phosphodiesterase-5 inhibition preserves renal hemodynamics and functi(epmc).pdf DeepDyve Pubget Overpricing