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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cardiovasc+Echogr
2013 ; 23
(1
): 33-38
Nephropedia Template TP
Monte I
; Bottari VE
; Buccheri S
; Blundo A
; Sirugo L
; Leggio S
; Licciardi S
J Cardiovasc Echogr
2013[Jan]; 23
(1
): 33-38
PMID28465881
show ga
OBJECTIVES: In our study, we aimed to identify early markers of cardiac
dysfunction in patients treated with mitoxantrone. We also looked at cardiac
functional changes during therapy by analyzing longitudinal deformation and by
measuring left ventricular (LV) and left atrial (LA) global strain. MATERIALS AND
METHODS: LA and LV global longitudinal strain were analyzed in 20 patients
affected by multiple sclerosis and treated with mitoxantrone. Patients underwent
echocardiography before treatment, after every drug administration during the
12-months treatment period, and finally after 6 and 12 months of drug
discontinuation. RESULTS: Compared with baseline values, patients showed a
significant reduction of both LA and LV longitudinal global strain at the end of
treatment with mitoxantrone (LA_GS% T10 vs. T0 values: 15,2 ± 12,5 vs. 20,2 ±
11,1; LV_GS%: ?16,4 ± 2,5 vs. ?17,4 ± 3,8). Strain reduction reverted after
treatment discontinuation (LA_GS% FU vs. T0 values: 20,4 ± 15,7 vs. 20,2 ± 11,1;
LV_GS%: ?17,3 ± 3,3 vs. ?17,4 ± 3,8). CONCLUSIONS: Impairment of longitudinal
deformation during mitoxantrone therapy may indicate a dysfunction related to
early myocardial damage. These findings appear to be reversible after treatment
discontinuation.