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10.18632/oncotarget.12830 http://scihub22266oqcxt.onion/10.18632/oncotarget.12830 C5352450!5352450!27784002     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (5): 8877-89 Nephropedia Template TP {{tp|p=27784002|t=2017. Next generation sequencing and its applications in HPVassociated cancers |pdf=|usr=}}{{27784002}} gab.com Text Next generation sequencing and its applications in HPVassociated cancers JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27784002 #FOAvip Approximately 18% of all human cancers have a viral etiology, and human papillomavirus (HPV) has been identified as one of the most prevalent viruses that plays causative role in nearly all cervical cancers and, in addition, in subset of head and neck, anal, penile and vulvar cancers. The recent introduction of next generation sequencing (NGS) and other omics approaches have resulted in comprehensive knowledge on the pathogenesis of HPV-driven tumors. Specifically, these approaches have provided detailed information on genomic HPV integration sites, disrupted genes and pathways, and common and distinct genetic and epigenetic alterations in different human HPV-associated cancers. This review focuses on HPV integration sites, its concomitantly disrupted genes and pathways and its functional consequences in both cervical and head and neck cancers. Integration of NGS data with other omics and clinical data is crucial to better understand the pathophysiology of each individual malignancy and, based on this, to select targets and to design effective personalized treatment options. Twit Text FOAVip Next generation sequencing and its applications in HPVassociated cancers ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27784002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27784002 #FOAvip English Wikipedia <ref>{{Cite pmid|27784002}}</ref> Next generation sequencing and its applications in HPVassociated cancers #MMPMID27784002 Tuna M; Amos CI Oncotarget 2017[Jan]; 8 (5): 8877-89 PMID27784002show ga Approximately 18% of all human cancers have a viral etiology, and human papillomavirus (HPV) has been identified as one of the most prevalent viruses that plays causative role in nearly all cervical cancers and, in addition, in subset of head and neck, anal, penile and vulvar cancers. The recent introduction of next generation sequencing (NGS) and other omics approaches have resulted in comprehensive knowledge on the pathogenesis of HPV-driven tumors. Specifically, these approaches have provided detailed information on genomic HPV integration sites, disrupted genes and pathways, and common and distinct genetic and epigenetic alterations in different human HPV-associated cancers. This review focuses on HPV integration sites, its concomitantly disrupted genes and pathways and its functional consequences in both cervical and head and neck cancers. Integration of NGS data with other omics and clinical data is crucial to better understand the pathophysiology of each individual malignancy and, based on this, to select targets and to design effective personalized treatment options. äNext generation sequencing and its applications in HPVassociated cance(epmc).pdf DeepDyve Pubget Overpricing