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10.18632/oncotarget.13853 http://scihub22266oqcxt.onion/10.18632/oncotarget.13853 C5352373!5352373!27974700     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (5): 7946-63 Nephropedia Template TP {{tp|p=27974700|t=2017. Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-?B inhibition in acute myeloid leukemia (AML) |pdf=|usr=}}{{27974700}} gab.com Text Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF- B inhibition in acute myeloid leukemia (AML) JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27974700 #FOAvip Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular communication in the leukemic bone marrow participates in disease development, progression and chemoresistance. Tunneling nanotubes (TNTs) are intercellular communication structures involved in transport of cellular contents and pathogens, also demonstrated to play a role in both cell death modulation and chemoresistance. Here we investigated the presence of TNTs by live fluorescent microscopy and identified TNT formation between primary AML cells and in AML cell lines. We found that NF-?B activity was involved in TNT regulation and formation. Cytarabine downregulated TNTs and inhibited NF-?B alone and in combination with daunorubicin, providing additional support for involvement of the NF-?B pathway in TNT formation. Interestingly, daunorubicin was found to localize to lysosomes in TNTs connecting AML cells indicating a novel function of TNTs as drug transporting devices. We conclude that TNT communication could reflect important biological features of AML that may be explored in future therapy development. Twit Text FOAVip Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF- B inhibition in acute myeloid leukemia (AML) ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27974700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27974700 #FOAvip English Wikipedia <ref>{{Cite pmid|27974700}}</ref> Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-?B inhibition in acute myeloid leukemia (AML) #MMPMID27974700 Omsland M; Bruserud Ø; Gjertsen BT; Andresen V Oncotarget 2017[Jan]; 8 (5): 7946-63 PMID27974700show ga Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular communication in the leukemic bone marrow participates in disease development, progression and chemoresistance. Tunneling nanotubes (TNTs) are intercellular communication structures involved in transport of cellular contents and pathogens, also demonstrated to play a role in both cell death modulation and chemoresistance. Here we investigated the presence of TNTs by live fluorescent microscopy and identified TNT formation between primary AML cells and in AML cell lines. We found that NF-?B activity was involved in TNT regulation and formation. Cytarabine downregulated TNTs and inhibited NF-?B alone and in combination with daunorubicin, providing additional support for involvement of the NF-?B pathway in TNT formation. Interestingly, daunorubicin was found to localize to lysosomes in TNTs connecting AML cells indicating a novel function of TNTs as drug transporting devices. We conclude that TNT communication could reflect important biological features of AML that may be explored in future therapy development. äTunneling nanotube (TNT) formation is downregulated by cytarabine and (epmc).pdf DeepDyve Pubget Overpricing