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2017 ; 8
(5
): 7336-7349
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Viral-host interaction in kidney reveals strategies to escape host immunity and
persistently shed virus to the urine
#MMPMID28038465
Ou X
; Mao S
; Jiang Y
; Zhang S
; Ke C
; Ma G
; Cheng A
; Wang M
; Zhu D
; Chen S
; Jia R
; Liu M
; Sun K
; Yang Q
; Wu Y
; Chen X
Oncotarget
2017[Jan]; 8
(5
): 7336-7349
PMID28038465
show ga
Hepatitis A virus is one of five types of hepatotropic viruses that cause human
liver disease. A similar liver disease is also identified in ducks caused by Duck
Hepatitis A virus (DHAV). Notably, many types of hepatotropic viruses can be
detected in urine. However, how those viruses enter into the urine is largely
unexplored. To elucidate the potential mechanism, we used the avian hepatotropic
virus to investigate replication strategies and immune responses in kidney until
280 days after infection. Immunohistochemistry and qPCR were used to detect viral
distribution and copies in the kidney. Double staining of CD4+ or CD8+ T cells
and virus and qPCR were used to investigate T cell immune responses and
expression levels of cytokines. Histopathology was detected by standard HE
staining. In this study, viruses were persistently located at scattered renal
tubules. No CD4+ or CD8+ T cells were recruited to the kidney, which was only
accompanied by transient cytokine storms. In conclusion, the extremely scattered
infection was the viral strategy to escape host immunity and may persistently
shed virus into urine. The deletion of Th or Tc cell responses and transient
cytokine storms indeed provide an advantageous renal environment for their
persistent survival.