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10.18632/oncotarget.14614 http://scihub22266oqcxt.onion/10.18632/oncotarget.14614 C5352323!5352323!28099916     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (5): 7315-27 Nephropedia Template TP {{tp|p=28099916|t=2017. Involvement of NF-?BIZ and related cytokines in age-associated renal fibrosis |pdf=|usr=}}{{28099916}} gab.com Text Involvement of NF- BIZ and related cytokines in age-associated renal fibrosis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28099916 #FOAvip Chronic inflammation is a major contributor to age-related nephropathic changes, including renal fibrosis. In this study, various experimental paradigms were designed to delineate the role played by NF-?BIZ (also known as I?B?) in age-associated renal fibrosis. Analyses based on RNA-sequencing findings obtained by next generation sequencing (NGS) revealed the upregulations of NF-?BIZ and of IL-6 and MCP-1 (both known to be regulated by NF-?BIZ) during aging. The up-regulation of NF-?BIZ in aged rat kidneys coincided with increased macrophage infiltration. In LPS-treated macrophages, oxidative stress was found to play a pivotal role in NF-?BIZ expression, suggesting age-related oxidative stress is associated with NF-?BIZ activation. Furthermore, these in vitro findings were confirmed in LPS-treated old rats, which showed higher levels of oxidative stress and NF-?BIZ in kidneys than LPS-treated young rats. Additional in vitro experiments using macrophages and kidney fibroblasts demonstrated NF-?BIZ and related cytokines participate in fibrosis. In particular, increased levels of NF-?BIZ-associated cytokines in macrophages significantly up-regulated TGF-? induced kidney fibroblast activation. Moreover, experiments with NF-?BIZ knocked down macrophages showed reduced TGF-?- induced kidney fibroblast activation. The findings of the present study provide evidence regarding an involvement of NF-?BIZ in age-associated progressive renal fibrosis and provides potential targets for its prevention. Twit Text FOAVip Involvement of NF- BIZ and related cytokines in age-associated renal fibrosis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28099916 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28099916 #FOAvip English Wikipedia <ref>{{Cite pmid|28099916}}</ref> Involvement of NF-?BIZ and related cytokines in age-associated renal fibrosis #MMPMID28099916 Chung KW; Jeong HO; Lee B; Park D; Kim DH; Choi YJ; Lee EK; Kim KM; Park JW; Yu BP; Chung HY Oncotarget 2017[Jan]; 8 (5): 7315-27 PMID28099916show ga Chronic inflammation is a major contributor to age-related nephropathic changes, including renal fibrosis. In this study, various experimental paradigms were designed to delineate the role played by NF-?BIZ (also known as I?B?) in age-associated renal fibrosis. Analyses based on RNA-sequencing findings obtained by next generation sequencing (NGS) revealed the upregulations of NF-?BIZ and of IL-6 and MCP-1 (both known to be regulated by NF-?BIZ) during aging. The up-regulation of NF-?BIZ in aged rat kidneys coincided with increased macrophage infiltration. In LPS-treated macrophages, oxidative stress was found to play a pivotal role in NF-?BIZ expression, suggesting age-related oxidative stress is associated with NF-?BIZ activation. Furthermore, these in vitro findings were confirmed in LPS-treated old rats, which showed higher levels of oxidative stress and NF-?BIZ in kidneys than LPS-treated young rats. Additional in vitro experiments using macrophages and kidney fibroblasts demonstrated NF-?BIZ and related cytokines participate in fibrosis. In particular, increased levels of NF-?BIZ-associated cytokines in macrophages significantly up-regulated TGF-? induced kidney fibroblast activation. Moreover, experiments with NF-?BIZ knocked down macrophages showed reduced TGF-?- induced kidney fibroblast activation. The findings of the present study provide evidence regarding an involvement of NF-?BIZ in age-associated progressive renal fibrosis and provides potential targets for its prevention. äInvolvement of NF-?BIZ and related cytokines in age-associated renal f(epmc).pdf DeepDyve Pubget Overpricing