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2017 ; 10
(ä): 1503-1512
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Silencing Trim59 inhibits invasion/migration and epithelial-to-mesenchymal
transition via TGF-?/Smad2/3 signaling pathway in bladder cancer cells
#MMPMID28331343
Chen W
; Zhao K
; Miao C
; Xu A
; Zhang J
; Zhu J
; Su S
; Wang Z
Onco Targets Ther
2017[]; 10
(ä): 1503-1512
PMID28331343
show ga
The evolutionarily conserved genes that encode the tripartite motif (TRIM)
protein family are involved in various biological processes, including cellular
immunity, inflammatory reaction, antiviral activity, and tumor progression. One
member of this protein family, Trim59, has been reported as a novel biomarker for
the occurrence and progression of multiple human carcinomas, such as lung cancer,
gastric cancer, cervical cancer, and osteosarcoma. However, little is known about
the relationship between Trim59 and bladder carcinogenesis. In this study, we
examined the expression of Trim59 in bladder cancer (Bca) specimens and cell
lines, and investigated its biological roles in Bca cell lines. We found that
Trim59 was upregulated in Bca tissues and cell lines. In addition, using
transwell chamber assays and the cell scratch test, we determined that knockdown
of Trim59 significantly inhibited the epithelial-mesenchymal transition (EMT) and
the processes of cell invasion and migration in Bca cell lines. Furthermore, we
found that downregulated Trim59 expression could also inhibit cell proliferation
and promote apoptosis. As a result, we demonstrated that the effects of
Trim59-induced EMT and invasion/migration in Bca cells were achieved by the
activation of the transforming growth factor beta/Smad2/3 signaling pathway. Our
findings also revealed that Trim59 can present oncogenic activity, and may serve
as a novel candidate target for bladder carcinoma treatment.
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