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10.18632/oncotarget.13661 http://scihub22266oqcxt.onion/10.18632/oncotarget.13661 C5352199!5352199 !27903982     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27903982 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (1 ): 819-832 Nephropedia Template TP {{tp|p=27903982 |t=2017. M2-like tumor-associated macrophages drive vasculogenic mimicry through amplification of IL-6 expression in glioma cells |pdf=|usr=}}{{27903982 }} gab.com Text M2-like tumor-associated macrophages drive vasculogenic mimicry through amplification of IL-6 expression in glioma cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27903982 #FOAvip Vasculogenic mimicry (VM) has offered a new horizon for understanding tumor angiogenesis, but the mechanisms of VM in glioma progression have not been studied explicitly until now. As a significant component of immune infiltration in tumor microenvironment, macrophages have been demonstrated to play an important role in tumor growth and angiogenesis. However, whether macrophages could play a potential key role in glioma VM is still poorly understood. Herein we reported that both VM and CD163+ cells were associated with WHO grade and reduced patient survival, and VM channel counting was correlated to the number of infiltrated CD163+ cells in glioma specimens. In vitro studies of glioma cell lines implicated that M2-like macrophages (M2) promoted glioma VM. We found that conditional medium derived from M2 amplified IL-6 expression in glioma cells. Furthermore, our data indicated that IL-6 could promote glioma VM, as blocking IL-6 with neutralizing antibodies abrogated M2-mediated VM enhancement. In addition, the potent PKC inhibitor bisindolylmaleimide I could prevent M2-induced IL-6 upregulation and further inhibited glioma VM facilitation. Taken together, our results suggested that M2-like macrophages drove glioma VM through amplifying IL-6 secretion in glioma cells via PKC pathway. Twit Text FOAVip M2-like tumor-associated macrophages drive vasculogenic mimicry through amplification of IL-6 expression in glioma cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27903982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27903982 #FOAvip English Wikipedia <ref>{{Cite pmid|27903982 }}</ref> M2-like tumor-associated macrophages drive vasculogenic mimicry through amplification of IL-6 expression in glioma cells #MMPMID27903982 Zhang L ; Xu Y ; Sun J ; Chen W ; Zhao L ; Ma C ; Wang Q ; Sun J ; Huang B ; Zhang Y ; Li X ; Qu X Oncotarget 2017[Jan]; 8 (1 ): 819-832 PMID27903982 show ga Vasculogenic mimicry (VM) has offered a new horizon for understanding tumor angiogenesis, but the mechanisms of VM in glioma progression have not been studied explicitly until now. As a significant component of immune infiltration in tumor microenvironment, macrophages have been demonstrated to play an important role in tumor growth and angiogenesis. However, whether macrophages could play a potential key role in glioma VM is still poorly understood. Herein we reported that both VM and CD163+ cells were associated with WHO grade and reduced patient survival, and VM channel counting was correlated to the number of infiltrated CD163+ cells in glioma specimens. In vitro studies of glioma cell lines implicated that M2-like macrophages (M2) promoted glioma VM. We found that conditional medium derived from M2 amplified IL-6 expression in glioma cells. Furthermore, our data indicated that IL-6 could promote glioma VM, as blocking IL-6 with neutralizing antibodies abrogated M2-mediated VM enhancement. In addition, the potent PKC inhibitor bisindolylmaleimide I could prevent M2-induced IL-6 upregulation and further inhibited glioma VM facilitation. Taken together, our results suggested that M2-like macrophages drove glioma VM through amplifying IL-6 secretion in glioma cells via PKC pathway. |*Gene Amplification [MESH] |Adult [MESH] |Aged [MESH] |Antigens, CD/metabolism [MESH] |Antigens, Differentiation, Myelomonocytic/metabolism [MESH] |Biomarkers [MESH] |CD163 Antigen [MESH] |Cell Line, Tumor [MESH] |Cytokines/genetics/metabolism [MESH] |Female [MESH] |Glioma/*etiology/metabolism/mortality/*pathology [MESH] |Humans [MESH] |Interleukin-6/*genetics/metabolism [MESH] |Kaplan-Meier Estimate [MESH] |Macrophages/immunology/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Models, Biological [MESH] |Neoplasm Grading [MESH] |Neoplasm Staging [MESH] |Neovascularization, Pathologic/*genetics/immunology [MESH] |Prognosis [MESH] |Protein Kinase C/metabolism [MESH] |Receptors, Cell Surface/metabolism [MESH]M2-like tumor-associated macrophages drive vasculogenic mimicry throug(epmc).pdf DeepDyve Pubget Overpricing