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10.18632/oncotarget.13393 http://scihub22266oqcxt.onion/10.18632/oncotarget.13393 C5352123!5352123 !27861147     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27861147 &cmd=llinks): Failed to open stream: HTTP request failed! 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Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy |pdf=|usr=}}{{27861147 }} gab.com Text Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27861147 #FOAvip Triple-negative breast cancers (TNBCs) are the most aggressive and hard-to-treat breast tumors with poor prognosis, and exploration for novel therapeutic drugs is impending. Arctigenin (Atn), a bioactive lignan isolated from seeds of Arctium lappa L, has been reported to inhibit many cancer types; however, the effect of Atn on TNBC remains unclear. In this study, we demonstrated that Atn decreased proliferation, and induced apoptosis in TNBC cells. Furthermore, we explored the underlying mechanism of Atn inhibition on TNBC cells. Computational docking and affinity assay showed that Atn bound to the SH2 domain of STAT3. Atn inhibited STAT3 binding to genomic DNA by disrupting hydrogen bond linking between DNA and STAT3. In addition, Atn augmented TaxotereŽ-induced TNBC cell cytotoxicity. TNBC xenograft tests also confirmed the antitumor effect of Atn in vivo. These characteristics render Atn as a promising candidate drug for further development and for designing new effective STAT3 inhibitors. Twit Text FOAVip Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27861147 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27861147 #FOAvip English Wikipedia <ref>{{Cite pmid|27861147 }}</ref> Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy #MMPMID27861147 Feng T ; Cao W ; Shen W ; Zhang L ; Gu X ; Guo Y ; Tsai HI ; Liu X ; Li J ; Zhang J ; Li S ; Wu F ; Liu Y Oncotarget 2017[Jan]; 8 (1 ): 329-344 PMID27861147 show ga Triple-negative breast cancers (TNBCs) are the most aggressive and hard-to-treat breast tumors with poor prognosis, and exploration for novel therapeutic drugs is impending. Arctigenin (Atn), a bioactive lignan isolated from seeds of Arctium lappa L, has been reported to inhibit many cancer types; however, the effect of Atn on TNBC remains unclear. In this study, we demonstrated that Atn decreased proliferation, and induced apoptosis in TNBC cells. Furthermore, we explored the underlying mechanism of Atn inhibition on TNBC cells. Computational docking and affinity assay showed that Atn bound to the SH2 domain of STAT3. Atn inhibited STAT3 binding to genomic DNA by disrupting hydrogen bond linking between DNA and STAT3. In addition, Atn augmented TaxotereŽ-induced TNBC cell cytotoxicity. TNBC xenograft tests also confirmed the antitumor effect of Atn in vivo. These characteristics render Atn as a promising candidate drug for further development and for designing new effective STAT3 inhibitors. |Animals [MESH] |Antineoplastic Agents/*pharmacology/therapeutic use [MESH] |Apoptosis/drug effects [MESH] |Arctium/*chemistry [MESH] |Asia, Eastern [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |DNA/metabolism [MESH] |Docetaxel [MESH] |Drug Evaluation, Preclinical [MESH] |Drug Synergism [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Furans/*pharmacology/therapeutic use [MESH] |Humans [MESH] |Hydrogen Bonding/drug effects [MESH] |Lignans/*pharmacology/therapeutic use [MESH] |Mice, Nude [MESH] |Molecular Docking Simulation [MESH] |Plants, Medicinal/chemistry [MESH] |Protein Domains [MESH] |STAT3 Transcription Factor/*antagonists & inhibitors/metabolism [MESH] |Signal Transduction/drug effects [MESH] |Taxoids/*pharmacology [MESH] |Triple Negative Breast Neoplasms/*drug therapy/pathology [MESH]Arctigenin inhibits STAT3 and exhibits anticancer potential in human (epmc).pdf DeepDyve Pubget Overpricing