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10.18632/oncotarget.13593 http://scihub22266oqcxt.onion/10.18632/oncotarget.13593 C5352045!5352045!27901481     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (1): 1177-89 Nephropedia Template TP {{tp|p=27901481|t=2017. Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia |pdf=|usr=}}{{27901481}} gab.com Text Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27901481 #FOAvip Cancer cachexia represents a debilitating syndrome that diminishes quality of life and augments the toxicities of conventional treatments. Cancer cachexia is particularly debilitating in patients with pancreatic cancer (PC). Mechanisms responsible for cancer cachexia are under investigation and are largely derived from observations in syngeneic murine models of cancer which are limited in PC. We evaluate the effect of human PC cells on both muscle wasting and the systemic inflammatory milieu potentially contributing to PC-associated cachexia. Specifically, human PC xenografts were generated by implantation of pancreatic cancer cells, L3.6pl and PANC-1, either in the flank or orthotopically within the pancreas. Mice bearing orthotopic xenografts demonstrated significant muscle wasting and atrophy-associated gene expression changes compared to controls. Further, despite the absence of adaptive immunity, splenic tissue from orthotopically engrafted mice demonstrated elevations in several pro-inflammatory cytokines associated with cancer cachexia, including TNF?, IL1?, IL6 and KC (murine IL8 homologue), when compared to controls. Therefore, data presented here support further investigation into the complexity of cancer cachexia in PC to identify potential targets for this debilitating syndrome. Twit Text FOAVip Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27901481 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27901481 #FOAvip English Wikipedia <ref>{{Cite pmid|27901481}}</ref> Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia #MMPMID27901481 Delitto D; Judge SM; Delitto AE; Nosacka RL; Rocha FG; DiVita BB; Gerber MH; George TJ; Behrns KE; Hughes SJ; Wallet SM; Judge AR; Trevino JG Oncotarget 2017[Jan]; 8 (1): 1177-89 PMID27901481show ga Cancer cachexia represents a debilitating syndrome that diminishes quality of life and augments the toxicities of conventional treatments. Cancer cachexia is particularly debilitating in patients with pancreatic cancer (PC). Mechanisms responsible for cancer cachexia are under investigation and are largely derived from observations in syngeneic murine models of cancer which are limited in PC. We evaluate the effect of human PC cells on both muscle wasting and the systemic inflammatory milieu potentially contributing to PC-associated cachexia. Specifically, human PC xenografts were generated by implantation of pancreatic cancer cells, L3.6pl and PANC-1, either in the flank or orthotopically within the pancreas. Mice bearing orthotopic xenografts demonstrated significant muscle wasting and atrophy-associated gene expression changes compared to controls. Further, despite the absence of adaptive immunity, splenic tissue from orthotopically engrafted mice demonstrated elevations in several pro-inflammatory cytokines associated with cancer cachexia, including TNF?, IL1?, IL6 and KC (murine IL8 homologue), when compared to controls. Therefore, data presented here support further investigation into the complexity of cancer cachexia in PC to identify potential targets for this debilitating syndrome. äHuman pancreatic cancer xenografts recapitulate key aspects of cancer (epmc).pdf DeepDyve Pubget Overpricing