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10.1371/journal.pone.0173629 http://scihub22266oqcxt.onion/10.1371/journal.pone.0173629 C5351998!5351998!28296922     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2017 ; 12 (3): ä Nephropedia Template TP {{tp|p=28296922|t=2017. The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine |pdf=|usr=}}{{28296922}} gab.com Text The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28296922 #FOAvip Osteopontin (Opn), a multifunctional extracellular matrix protein, is implicated in the pathogenesis of various inflammatory disorders. Under physiologic conditions, its expression is restricted to certain tissues including bone and kidney tubule. However, cellular activation during disease development induces Opn expression in various immune cells. In this study, using Opn-EGFP knock-in (KI) mice we found that CD8?+ T cells in the intestinal tissues, including Peyer?s patch, lamina propria and epithelium, express Opn under steady state conditions. Therefore, we examined the role of Opn-expressing CD8?+ T cells in intestinal homeostasis. Interestingly, Opn knockout (KO) mice had altered fecal microflora concordant with a reduction of TCR??+ intraepithelial lymphocytes (IELs). Consistent with this result, both treatment with anti-Opn blocking antibody and deficiency of Opn resulted in decreased survival of TCR??+ and TCR??+ IELs. This data suggests that a possibility that Opn may function as a survival factor for IELs in the intestinal tissue. Collectively, these data suggest the possibility that Opn might regulate the homeostasis of intestinal microflora through maintenance of TCR??+ IELs, possibly by support of IEL survival. Twit Text FOAVip The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28296922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28296922 #FOAvip English Wikipedia <ref>{{Cite pmid|28296922}}</ref> The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine #MMPMID28296922 Ito K; Nakajima A; Fukushima Y; Suzuki K; Sakamoto K; Hamazaki Y; Ogasawara K; Minato N; Hattori M PLoS One 2017[]; 12 (3): ä PMID28296922show ga Osteopontin (Opn), a multifunctional extracellular matrix protein, is implicated in the pathogenesis of various inflammatory disorders. Under physiologic conditions, its expression is restricted to certain tissues including bone and kidney tubule. However, cellular activation during disease development induces Opn expression in various immune cells. In this study, using Opn-EGFP knock-in (KI) mice we found that CD8?+ T cells in the intestinal tissues, including Peyer?s patch, lamina propria and epithelium, express Opn under steady state conditions. Therefore, we examined the role of Opn-expressing CD8?+ T cells in intestinal homeostasis. Interestingly, Opn knockout (KO) mice had altered fecal microflora concordant with a reduction of TCR??+ intraepithelial lymphocytes (IELs). Consistent with this result, both treatment with anti-Opn blocking antibody and deficiency of Opn resulted in decreased survival of TCR??+ and TCR??+ IELs. This data suggests that a possibility that Opn may function as a survival factor for IELs in the intestinal tissue. Collectively, these data suggest the possibility that Opn might regulate the homeostasis of intestinal microflora through maintenance of TCR??+ IELs, possibly by support of IEL survival. äThe potential role of Osteopontin in the maintenance of commensal bact(epmc).pdf DeepDyve Pubget Overpricing