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10.1126/science.aai9127 http://scihub22266oqcxt.onion/10.1126/science.aai9127 C5351859!5351859!27934701     free     free     free       Science 2016 ; 354 (6318): 1437-40 Nephropedia Template TP {{tp|p=27934701|t=2016. Translational termination without a stop codon |pdf=|usr=}}{{27934701}} gab.com Text Translational termination without a stop codon JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27934701 #FOAvip Ribosomes stall when they encounter the end of mRNA without an in-frame stop codon. In bacteria, these nonstop complexes can be rescued by alternative ribosome-rescue factor A (ArfA). Here, using electron cryomicroscopy, we have determined structures of ArfA bound to the ribosome with 3?-truncated mRNA to resolutions from 3.0 to 3.4 Å. ArfA binds within the ribosomal mRNA channel and substitutes for the absent stop codon in the A site by specifically recruiting release factor 2 (RF2), initially in a compact pre-accommodated state. A similar conformation of RF2 may occur on stop codons, suggesting a general mechanism for release-factor-mediated translational termination in which a conformational switch leads to peptide release only when the appropriate signal is present in the A site. Twit Text FOAVip Translational termination without a stop codon ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27934701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27934701 #FOAvip English Wikipedia <ref>{{Cite pmid|27934701}}</ref> Translational termination without a stop codon #MMPMID27934701 James NR; Brown A; Gordiyenko Y; Ramakrishnan V Science 2016[Dec]; 354 (6318): 1437-40 PMID27934701show ga Ribosomes stall when they encounter the end of mRNA without an in-frame stop codon. In bacteria, these nonstop complexes can be rescued by alternative ribosome-rescue factor A (ArfA). Here, using electron cryomicroscopy, we have determined structures of ArfA bound to the ribosome with 3?-truncated mRNA to resolutions from 3.0 to 3.4 Å. ArfA binds within the ribosomal mRNA channel and substitutes for the absent stop codon in the A site by specifically recruiting release factor 2 (RF2), initially in a compact pre-accommodated state. A similar conformation of RF2 may occur on stop codons, suggesting a general mechanism for release-factor-mediated translational termination in which a conformational switch leads to peptide release only when the appropriate signal is present in the A site. äTranslational termination without a stop codon (epmc).pdf DeepDyve Pubget Overpricing