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10.1016/j.ccc.2016.12.001 http://scihub22266oqcxt.onion/10.1016/j.ccc.2016.12.001 C5351769!5351769!28284293     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care+Clin 2017 ; 33 (2): 245-58 Nephropedia Template TP {{tp|p=28284293|t=2017. Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) |pdf=|usr=}}{{28284293}} gab.com Text Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) JO: Crit Care Clin http://www.kidney.de/pget.php?&tw=1&pmid=28284293 #FOAvip Over the past four decades the epidemiology of multiple organ failure (MOF) has evolved as a result of advances in care. A series of paradigms have been described to explain the pathophysiology of the new emerging predominant phenotypes. With the most recent improvements in the delivery of critical care, patients are less-frequently expiring early in their clinical course and in-hospital MOF-related mortality is on the decline. Unfortunately, this has resulted in a dramatic increase in the number of chronic critically ill patients (CCI) who linger in the intensive care unit (ICU), have high resource utilization, are discharged to non-home locations, experience sepsis recidivism requiring readmission, have persistent cognitive and functional impairments, and poor long-term survival. Within this population, we have proposed that a substantial subset of these patients suffer from a new phenotype termed Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) which underlies these poor outcomes. While the mechanism(s) of PICS are under investigation, there is evidence that myelodysplasia with expansion of myeloid derived suppressor cells, innate and adaptive immune suppression and protein catabolism with malnutrition are major contributors. Optimal care of these patients will require a novel multimodality intervention using pharmacotherapy, physiotherapy and nutritional support. Twit Text FOAVip Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) ????Crit Care Clin http://www.kidney.de/pget.php?&tw=1&pmid=28284293 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28284293 #FOAvip English Wikipedia <ref>{{Cite pmid|28284293}}</ref> Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) #MMPMID28284293 Mira JC; Brakenridge SC; Moldawer LL; Moore FA Crit Care Clin 2017[Apr]; 33 (2): 245-58 PMID28284293show ga Over the past four decades the epidemiology of multiple organ failure (MOF) has evolved as a result of advances in care. A series of paradigms have been described to explain the pathophysiology of the new emerging predominant phenotypes. With the most recent improvements in the delivery of critical care, patients are less-frequently expiring early in their clinical course and in-hospital MOF-related mortality is on the decline. Unfortunately, this has resulted in a dramatic increase in the number of chronic critically ill patients (CCI) who linger in the intensive care unit (ICU), have high resource utilization, are discharged to non-home locations, experience sepsis recidivism requiring readmission, have persistent cognitive and functional impairments, and poor long-term survival. Within this population, we have proposed that a substantial subset of these patients suffer from a new phenotype termed Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) which underlies these poor outcomes. While the mechanism(s) of PICS are under investigation, there is evidence that myelodysplasia with expansion of myeloid derived suppressor cells, innate and adaptive immune suppression and protein catabolism with malnutrition are major contributors. Optimal care of these patients will require a novel multimodality intervention using pharmacotherapy, physiotherapy and nutritional support. äPersistent Inflammation, Immunosuppression and Catabolism Syndrome (PI(epmc).pdf DeepDyve Pubget Overpricing