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2017 ; 6
(2
): 157-162
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Sclerosing adenosis: Ultrasonographic and mammographic findings and correlation
with histopathology
#MMPMID28357084
Chen YL
; Chen JJ
; Chang C
; Gao Y
; Wu J
; Yang WT
; Gu YJ
Mol Clin Oncol
2017[Feb]; 6
(2
): 157-162
PMID28357084
show ga
The present study was conducted to evaluate the radiological findings,
particularly the ultrasonographic (US) characteristics of sclerosing adenosis
(SA), and their correlation with histopathological results. A retrospective
review identified 191 patients with a total of 200 lesions histopathologically
confirmed as SA following breast surgery between July 2009 and December 2012. Of
the 191 patients, 145 (151 lesions) with SA as the major component were included
for US and mammographic (MG) analysis. All 145 patients analyzed were female,
with a mean age ± standard deviation of 46.8±7.8 years (range, 25-71 years). All
145 patients underwent US examination and the imaging findings included
heterogeneously echogenic areas in 9.3% (14/151), masses in 51.7% (78/151),
masses with calcifications in 13.9% (21/151), focal acoustic shadowing in 4.0%
(6/151) and were negative in 21.2% (32/151) patients. Among the 119 lesions with
visible abnormalities, 87.4% (104/119) were hypoechoic, 58.0% (69/119) were
irregular in shape, 52.1% (62/119) had an ill-defined margin, calcifications were
found in 17.6% (21/119) and 7.6% (9/119) were hypervascular, while none of the
characteristics mentioned above were significantly correlated with
histopathology. A total of 136 patients underwent MG at the Fudan University
Shanghai Cancer Center, and the imaging findings included microcalcifications in
31.6% (43/136), masses in 23.5% (32/136), asymmetric focal density in 14.7%
(20/136), focal architectural distortion in 22.8% (31/136), and were negative in
7.4% (10/136). The mass lesions were fewer on MG compared with US (23.5 vs.
65.6%, respectively). The area under the curve of US distinguishing between
benign and malignant lesions was significantly larger compared with that of MG
(0.547 vs. 0.497, respectively; P=0.036). In the 60 lesions that were
overestimated by Breast Imaging Reporting and Data System US category, one or
more characteristics of malignancy were found on US imaging. The most common
finding of SA was masses with or without calcifications on US and
microcalcifications on MG. The accuracy of US was limited, but higher compared
with that of MG; however, SA mimicking the characteristics of malignancy may
contribute to misdiagnosis with US.
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