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10.3892/ol.2016.5473 http://scihub22266oqcxt.onion/10.3892/ol.2016.5473 C5351347!5351347!28356986     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28356986.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncol+Lett 2017 ; 13 (2): 967-72 Nephropedia Template TP {{tp|p=28356986|t=2017. Hypoxia regulates CD44 expression via hypoxia-inducible factor-1? in human gastric cancer cells |pdf=|usr=}}{{28356986}} gab.com Text Hypoxia regulates CD44 expression via hypoxia-inducible factor-1 in human gastric cancer cells JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28356986 #FOAvip Hypoxia induces proliferation and invasion in cancer cells via hypoxia-inducible factor (HIF)-1?. The cell adhesion molecule cluster of differentiation (CD) 44 has been associated with increased cell invasion and metastasis. Whether hypoxia regulates the expression of CD44 in gastric cancer cells remains to be established. In the current study, the effects of hypoxia on HIF-1? and CD44 expression levels in human gastric cell lines SGC-7901 and BGC-823 were evaluated. The cells were cultured in 1% O2 for 1 week and then treated with 20 nM rapamycin for 72 h. Cell viability was evaluated using the Cell Counting kit-8 assay, and cell invasion was detected by the Transwell invasion assay. The protein and messenger (m) RNA expression levels of HIF-1? and CD44 were detected using western blotting and reverse transcription-quantitative polymerase chain reaction, respectively. The results revealed that cell viability and invasion increased under hypoxic conditions, but decreased following rapamycin treatment in SGC-7901 and BGC-823 cells. Hypoxia also increased the protein and mRNA expression levels of HIF-1? and CD44 in these two cell lines. However, this hypoxia-induced increase in HIF-1? and CD44 protein and mRNA expression levels was inhibited by rapamycin. These findings suggest that hypoxia induced the proliferation and invasion of SGC-7901 and BGC-823 cells. Furthermore, CD44 expression levels were potentially associated with HIF-1? expression levels. Therefore, in gastric cancer cells, hypoxia may regulate CD44 expression via HIF-1? in order to promote cell proliferation and invasion. Twit Text FOAVip Hypoxia regulates CD44 expression via hypoxia-inducible factor-1 in human gastric cancer cells ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28356986 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28356986 #FOAvip English Wikipedia <ref>{{Cite pmid|28356986}}</ref> Hypoxia regulates CD44 expression via hypoxia-inducible factor-1? in human gastric cancer cells #MMPMID28356986 Liang G; Li S; Du W; Ke Q; Cai J; Yang J Oncol Lett 2017[Feb]; 13 (2): 967-72 PMID28356986show ga Hypoxia induces proliferation and invasion in cancer cells via hypoxia-inducible factor (HIF)-1?. The cell adhesion molecule cluster of differentiation (CD) 44 has been associated with increased cell invasion and metastasis. Whether hypoxia regulates the expression of CD44 in gastric cancer cells remains to be established. In the current study, the effects of hypoxia on HIF-1? and CD44 expression levels in human gastric cell lines SGC-7901 and BGC-823 were evaluated. The cells were cultured in 1% O2 for 1 week and then treated with 20 nM rapamycin for 72 h. Cell viability was evaluated using the Cell Counting kit-8 assay, and cell invasion was detected by the Transwell invasion assay. The protein and messenger (m) RNA expression levels of HIF-1? and CD44 were detected using western blotting and reverse transcription-quantitative polymerase chain reaction, respectively. The results revealed that cell viability and invasion increased under hypoxic conditions, but decreased following rapamycin treatment in SGC-7901 and BGC-823 cells. Hypoxia also increased the protein and mRNA expression levels of HIF-1? and CD44 in these two cell lines. However, this hypoxia-induced increase in HIF-1? and CD44 protein and mRNA expression levels was inhibited by rapamycin. These findings suggest that hypoxia induced the proliferation and invasion of SGC-7901 and BGC-823 cells. Furthermore, CD44 expression levels were potentially associated with HIF-1? expression levels. Therefore, in gastric cancer cells, hypoxia may regulate CD44 expression via HIF-1? in order to promote cell proliferation and invasion. äHypoxia regulates CD44 expression via hypoxia-inducible factor-1? in h(epmc).pdf DeepDyve Pubget Overpricing