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2016 ; 9
(4
): 207-15
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Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4
Protein Expression and Metabolic Enzymes
#MMPMID27277845
Jing J
; Isoherranen N
; Robinson-Cohen C
; Petrie I
; Kestenbaum BR
; Yeung CK
Clin Transl Sci
2016[Aug]; 9
(4
): 207-15
PMID27277845
show ga
Vitamin A, via retinoic acid (RA), is a critical micronutrient. Normally, plasma
concentrations are tightly regulated. Concentrations of vitamin A metabolites
(13cis-RA, atRA) and relationships between RBP4 and retinoids have never been
fully evaluated in adult patients with CKD. We measured retinoid and RBP4
concentrations in plasma and urine from 55 adult patients with CKD and 21 matched
healthy subjects. RBP4 and retinol levels were increased approximately twofold in
patients with CKD, with a negative correlation between plasma retinol and eGFR (p
= 0.006) and plasma RBP4 and eGFR (p = 0.0007). RBP4 renal clearance was higher
in patients with CKD than healthy subjects but not associated with eGFR.
Circulating concentrations of atRA increased and concentrations of 13cis-RA
decreased in subjects with CKD with no change in RA-to-retinol ratio. Increases
in circulating retinol, RBP4, and atRA may be due to increased hepatic RBP4
synthesis, retinyl ester hydrolysis, and/or hepatic secretion of RBP4-retinol.