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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Transl+Sci
2016 ; 9
(5
): 252-259
Nephropedia Template TP
gab.com Text
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English Wikipedia
Endoxifen, a New Treatment Option for Mania: A Double-Blind, Active-Controlled
Trial Demonstrates the Antimanic Efficacy of Endoxifen
#MMPMID27346789
Ahmad A
; Sheikh S
; Shah T
; Reddy MS
; Prasad B
; Verma KK
; Chandrakant BB
; Paithankar M
; Kale P
; Solanki RV
; Patel R
; Barkate H
; Ahmad I
Clin Transl Sci
2016[Oct]; 9
(5
): 252-259
PMID27346789
show ga
The protein kinase C (PKC) signaling system plays a role in mood disorders and
PKC inhibitors such as endoxifen may be an innovative medicine for bipolar
disorder (BP) patients. In this study we show for the first time the antimanic
properties of endoxifen in patients with bipolar I disorder (BPD I) with current
manic or mixed episode. In a double-blind, active-controlled study, 84 subjects
with BPD I were randomly assigned to receive endoxifen (4 mg/day or 8 mg/day) or
divalproex in a 2:1 ratio. Patients orally administered 4 mg/day or 8 mg/day
endoxifen showed significant improvement in mania assessed by the Young Mania
Rating Scale as early as 4 days. The effect remained significant throughout the
21-day period. At study end point, response rates were 44.44% and 64.29% at 4
mg/day and 8 mg/day of endoxifen treatment, respectively. Thus, endoxifen has
been shown as a promising novel antimanic or mood stabilizing agent.