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10.1038/nature17941 http://scihub22266oqcxt.onion/10.1038/nature17941 C5350615!5350615!27120162     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2016 ; 533 (7601): 90-4 Nephropedia Template TP {{tp|p=27120162|t=2016. Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture |pdf=|usr=}}{{27120162}} gab.com Text Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=27120162 #FOAvip Circuits in visual cortex integrate the information derived from separate ON and OFF pathways to construct orderly columnar representations of orientation and visual space1?7. How this transformation is achieved to meet the specific topographic constraints of each representation remains unclear. Here we report several novel features of ON/OFF convergence visualized by mapping the receptive fields of layer 2/3 neurons in tree shrew visual cortex using two-photon imaging of GCaMP6 calcium signals. The spatially separate ON and OFF subfields of simple cells in layer 2/3 were found to exhibit topologically distinct relationships with the maps of visual space and orientation preference. The centers of OFF subfields for neurons in a given region of cortex were confined to a compact region of visual space and displayed a smooth visuotopic progression. In contrast, the centers of the ON subfields were distributed over a wider region of visual space, displayed significant visuotopic scatter, and an orientation-specific displacement consistent with orientation preference map structure. As a result, cortical columns exhibit an invariant aggregate receptive field structure: an OFF-dominated central region flanked by ON-dominated subfields. This distinct arrangement of ON- and OFF- inputs enables continuity in the mapping of both orientation and visual space and the generation of a columnar map of absolute spatial phase. Twit Text FOAVip Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=27120162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27120162 #FOAvip English Wikipedia <ref>{{Cite pmid|27120162}}</ref> Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture #MMPMID27120162 Lee KS; Huang X; Fitzpatrick D Nature 2016[May]; 533 (7601): 90-4 PMID27120162show ga Circuits in visual cortex integrate the information derived from separate ON and OFF pathways to construct orderly columnar representations of orientation and visual space1?7. How this transformation is achieved to meet the specific topographic constraints of each representation remains unclear. Here we report several novel features of ON/OFF convergence visualized by mapping the receptive fields of layer 2/3 neurons in tree shrew visual cortex using two-photon imaging of GCaMP6 calcium signals. The spatially separate ON and OFF subfields of simple cells in layer 2/3 were found to exhibit topologically distinct relationships with the maps of visual space and orientation preference. The centers of OFF subfields for neurons in a given region of cortex were confined to a compact region of visual space and displayed a smooth visuotopic progression. In contrast, the centers of the ON subfields were distributed over a wider region of visual space, displayed significant visuotopic scatter, and an orientation-specific displacement consistent with orientation preference map structure. As a result, cortical columns exhibit an invariant aggregate receptive field structure: an OFF-dominated central region flanked by ON-dominated subfields. This distinct arrangement of ON- and OFF- inputs enables continuity in the mapping of both orientation and visual space and the generation of a columnar map of absolute spatial phase. äTopology of ON and OFF inputs in visual cortex enables an invariant co(epmc).pdf DeepDyve Pubget Overpricing