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Survival of macrovascular disease, chronic kidney disease, chronic respiratory
disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan
cohort
#MMPMID28209242
Yokomichi H
; Nagai A
; Hirata M
; Kiyohara Y
; Muto K
; Ninomiya T
; Matsuda K
; Kamatani Y
; Tamakoshi A
; Kubo M
; Nakamura Y
; Yamagata Z
J Epidemiol
2017[Mar]; 27
(3S
): S98-S106
PMID28209242
show ga
BACKGROUND: The number of patients with diabetes is increasing worldwide.
Macrovascular disease, chronic kidney disease, chronic respiratory disease,
cancer and smoking frequently accompany type 2 diabetes. Few data are available
related to mortality of Asians with diabetes associated with these serious
comorbidities. The present study aimed to quantify the excess mortality risks of
type 2 diabetic patients with comorbidities. METHODS: We analysed the available
records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan
Project between 2003 and 2007. Men and women were followed up for median 8.03 and
8.30 years, respectively. We applied Cox proportional hazard model and
Kaplan-Meier estimates for survival curves to evaluate mortality in diabetic
patients with or without macrovascular disease, chronic respiratory disease,
chronic kidney disease, cancer and smoking. RESULTS: Adjusted hazard ratios (HRs)
for mortality were 1.39 (95% CI, 1.09-1.78) for male sex, 2.01 (95% CI,
1.78-2.26) per 10-year increment of age. Adjusted HRs of primary interest were
1.77 (95% CI, 1.42-2.22), macrovascular disease; 1.58 (95% CI, 1.08-2.31),
chronic respiratory disease; 2.03 (95% CI, 1.67-2.47), chronic kidney disease;
1.16 (95% CI, 0.86-1.56), cancer; and 1.74 (95% CI, 1.30-2.31), current smoking.
CONCLUSIONS: Diabetic patients with a past or current history of chronic kidney,
macrovascular or respiratory diseases or smoking habit have exhibited the highest
risk of mortality. Data were limited to those of survivors of comorbidities but
we propose the need to improve comorbidities and terminate cigarette smoking for
better prognosis in patients with diabetes.
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Biological Specimen Banks
[MESH]
|Chronic Disease
[MESH]
|Cohort Studies
[MESH]
|Comorbidity
[MESH]
|Diabetes Complications/epidemiology
[MESH]
|Diabetes Mellitus, Type 2/*epidemiology/mortality
[MESH]
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