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10.1083/jcb.201512012 http://scihub22266oqcxt.onion/10.1083/jcb.201512012 C5350508!5350508 !28130292     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28130292 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2017 ; 216 (3 ): 779-792 Nephropedia Template TP {{tp|p=28130292 |t=2017. Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation |pdf=|usr=}}{{28130292 }} gab.com Text Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28130292 #FOAvip Dendritic cells (DCs) promote either tolerogenic or immunogenic T cell responses, the latter upon sensing microbes. Using an in vitro system, we analyzed transcriptional determinants that enable mature DCs to direct these opposing T cell outcomes. In the absence of microbial products, the transcription factor interferon regulatory factor 4 (IRF4) promotes regulatory T cell (T(reg)) generation by enhancing expression of genes required for antigen presentation along with those for T cell tolerance. IRF4-deficient DCs were impaired for T(reg) generation in vivo. When exposed to microbial stimuli, DCs activated nuclear factor (NF)-?B, which induced expression of a proinflammatory cytokine module that, along with the antigen presentation module, promoted the generation of effector T cells. NF-?B was, however, dispensable for T(reg) development. Chromatin profiling revealed transcriptional motifs associated with the divergent DC programs. Thus, DCs modulate their ability to prime tolerogenic or immunogenic T cells by expressing a core antigen presentation module that is overlaid by distinctive regulatory modules to promote either tolerance or immunity. Twit Text FOAVip Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28130292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28130292 #FOAvip English Wikipedia <ref>{{Cite pmid|28130292 }}</ref> Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation #MMPMID28130292 Vander Lugt B ; Riddell J ; Khan AA ; Hackney JA ; Lesch J ; DeVoss J ; Weirauch MT ; Singh H ; Mellman I J Cell Biol 2017[Mar]; 216 (3 ): 779-792 PMID28130292 show ga Dendritic cells (DCs) promote either tolerogenic or immunogenic T cell responses, the latter upon sensing microbes. Using an in vitro system, we analyzed transcriptional determinants that enable mature DCs to direct these opposing T cell outcomes. In the absence of microbial products, the transcription factor interferon regulatory factor 4 (IRF4) promotes regulatory T cell (T(reg)) generation by enhancing expression of genes required for antigen presentation along with those for T cell tolerance. IRF4-deficient DCs were impaired for T(reg) generation in vivo. When exposed to microbial stimuli, DCs activated nuclear factor (NF)-?B, which induced expression of a proinflammatory cytokine module that, along with the antigen presentation module, promoted the generation of effector T cells. NF-?B was, however, dispensable for T(reg) development. Chromatin profiling revealed transcriptional motifs associated with the divergent DC programs. Thus, DCs modulate their ability to prime tolerogenic or immunogenic T cells by expressing a core antigen presentation module that is overlaid by distinctive regulatory modules to promote either tolerance or immunity. |Animals [MESH] |Antigen Presentation/genetics/immunology [MESH] |Cell Differentiation/genetics/immunology [MESH] |Cytokines/metabolism [MESH] |Dendritic Cells/*immunology/metabolism/*physiology [MESH] |Immune Tolerance/*genetics/*immunology/physiology [MESH] |Interferon Regulatory Factors/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |NF-kappa B/metabolism [MESH] |T-Lymphocytes, Regulatory/immunology/metabolism/physiology [MESH]Transcriptional determinants of tolerogenic and immunogenic states dur(epmc).pdf DeepDyve Pubget Overpricing