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Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with
Membranous Nephropathy
#MMPMID28337458
Wang S
; Lu Y
; Hong Q
; Geng X
; Wang X
; Zheng W
; Song C
; Liu C
; Fan M
; Xi Y
; Guo M
; Wu D
Biomed Res Int
2017[]; 2017
(?): 7843584
PMID28337458
show ga
Membranous nephropathy (MN) is an autoimmune inflammatory disease in which
proteins related with plenty of biological processes play an important role.
However, the role of these proteins in the pathogenesis of MN is still unclear.
This study aimed to screen differential proteins in kidney tissue samples from MN
patients by using protein arrays and determine the pathways involved in the
pathogenesis of MN. This study first tested a quantitative protein array
(QAH-INF-3) and two semiquantitative protein arrays (L-493 and L-507) with normal
renal tissue and identified L-493 as the most appropriate assay to compare
protein levels between MN tissues and normal control tissues. The L-493 array
identified 66 differentially expressed proteins (DEPs) that may be associated
with MN. The gene oncology (GO) and protein-protein interaction (PPI) analyses
revealed several processes potentially involved in MN, including extracellular
matrix disassembly and organization, cell adhesion, cell-cell signaling, cellular
protein metabolic process, and immune response (P < 0.05). We suggest that these
different pathways work together via protein signaling and result in the
pathogenesis and progression of MN.
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