Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/mi.2016.80 http://scihub22266oqcxt.onion/10.1038/mi.2016.80 C5350071!5350071!27624780     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mucosal+Immunol 2017 ; 10 (3): 673-84 Nephropedia Template TP {{tp|p=27624780|t=2017. IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria |pdf=|usr=}}{{27624780}} gab.com Text IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27624780 #FOAvip Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces Th17 cell differentiation in the intestine, yet the effector functions of IL-17A in response to SFB remain incompletely understood. Here, we report that colonization of mice with SFB-containing microbiota induced IL-17A- and CXCR2-dependent recruitment of neutrophils to the ileum. This response required adaptive immunity as Rag-deficient mice colonized with SFB-containing microbiota failed to induce IL-17A, CXCL1 and CXCL2, and displayed defective neutrophil recruitment to the ileum. Interestingly, neutrophil depletion in wild-type mice resulted in significantly augmented Th17 responses and SFB expansion, which correlated with impaired expression of IL-22 and antimicrobial peptides. These data provide novel insight into a dynamic IL-17A-CXCR2-neutrophil axis during acute SFB colonization and demonstrate a central role for neutrophils in limiting SFB expansion. Twit Text FOAVip IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27624780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27624780 #FOAvip English Wikipedia <ref>{{Cite pmid|27624780}}</ref> IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria #MMPMID27624780 Flannigan KL; Ngo VL; Geem D; Harusato A; Hirota SA; Parkos CA; Lukacs NW; Nusrat A; Gaboriau-Routhiau V; Cerf-Bensussan N; Gewirtz AT; Denning TL Mucosal Immunol 2017[May]; 10 (3): 673-84 PMID27624780show ga Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces Th17 cell differentiation in the intestine, yet the effector functions of IL-17A in response to SFB remain incompletely understood. Here, we report that colonization of mice with SFB-containing microbiota induced IL-17A- and CXCR2-dependent recruitment of neutrophils to the ileum. This response required adaptive immunity as Rag-deficient mice colonized with SFB-containing microbiota failed to induce IL-17A, CXCL1 and CXCL2, and displayed defective neutrophil recruitment to the ileum. Interestingly, neutrophil depletion in wild-type mice resulted in significantly augmented Th17 responses and SFB expansion, which correlated with impaired expression of IL-22 and antimicrobial peptides. These data provide novel insight into a dynamic IL-17A-CXCR2-neutrophil axis during acute SFB colonization and demonstrate a central role for neutrophils in limiting SFB expansion. äIL-17A-mediated neutrophil recruitment limits expansion of segmented f(epmc).pdf DeepDyve Pubget Overpricing