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10.18632/oncotarget.13466 http://scihub22266oqcxt.onion/10.18632/oncotarget.13466 C5349955!5349955 !27888804     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27888804 &cmd=llinks): Failed to open stream: HTTP request failed! 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Niclosamide and its analogs are potent inhibitors of Wnt/?-catenin, mTOR and STAT3 signaling in ovarian cancer |pdf=|usr=}}{{27888804 }} gab.com Text Niclosamide and its analogs are potent inhibitors of Wnt/ -catenin, mTOR and STAT3 signaling in ovarian cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27888804 #FOAvip Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer mortality worldwide. Platinum-based therapy is the standard first line treatment and while most patients initially respond, resistance to chemotherapy usually arises. Major signaling pathways frequently upregulated in chemoresistant cells and important in the maintenance of cancer stem cells (CSCs) include Wnt/?-catenin, mTOR, and STAT3. The major objective of our study was to investigate the treatment of ovarian cancer with targeted agents that inhibit these three pathways. Here we demonstrate that niclosamide, a salicylamide derivative, and two synthetically manufactured niclosamide analogs (analog 11 and 32) caused significant inhibition of proliferation of two chemoresistant ovarian cancer cell lines (A2780cp20 and SKOV3Trip2), tumorspheres isolated from the ascites of EOC patients, and cells from a chemoresistant patient-derived xenograft (PDX). This work shows that all three agents significantly decreased the expression of proteins in the Wnt/?-catenin, mTOR and STAT3 pathways and preferentially targeted cells that expressed the ovarian CSC surface protein CD133. It also illustrates the potential of drug repurposing for chemoresistant EOC and can serve as a basis for pathway-oriented in vivo studies. Twit Text FOAVip Niclosamide and its analogs are potent inhibitors of Wnt/ -catenin, mTOR and STAT3 signaling in ovarian cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27888804 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27888804 #FOAvip English Wikipedia <ref>{{Cite pmid|27888804 }}</ref> Niclosamide and its analogs are potent inhibitors of Wnt/?-catenin, mTOR and STAT3 signaling in ovarian cancer #MMPMID27888804 Arend RC ; Londoņo-Joshi AI ; Gangrade A ; Katre AA ; Kurpad C ; Li Y ; Samant RS ; Li PK ; Landen CN ; Yang ES ; Hidalgo B ; Alvarez RD ; Straughn JM ; Forero A ; Buchsbaum DJ Oncotarget 2016[Dec]; 7 (52 ): 86803-86815 PMID27888804 show ga Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer mortality worldwide. Platinum-based therapy is the standard first line treatment and while most patients initially respond, resistance to chemotherapy usually arises. Major signaling pathways frequently upregulated in chemoresistant cells and important in the maintenance of cancer stem cells (CSCs) include Wnt/?-catenin, mTOR, and STAT3. The major objective of our study was to investigate the treatment of ovarian cancer with targeted agents that inhibit these three pathways. Here we demonstrate that niclosamide, a salicylamide derivative, and two synthetically manufactured niclosamide analogs (analog 11 and 32) caused significant inhibition of proliferation of two chemoresistant ovarian cancer cell lines (A2780cp20 and SKOV3Trip2), tumorspheres isolated from the ascites of EOC patients, and cells from a chemoresistant patient-derived xenograft (PDX). This work shows that all three agents significantly decreased the expression of proteins in the Wnt/?-catenin, mTOR and STAT3 pathways and preferentially targeted cells that expressed the ovarian CSC surface protein CD133. It also illustrates the potential of drug repurposing for chemoresistant EOC and can serve as a basis for pathway-oriented in vivo studies. |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Apoptosis/drug effects [MESH] |Cell Cycle Checkpoints/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Female [MESH] |Humans [MESH] |Mice [MESH] |Niclosamide/analogs & derivatives/*pharmacology [MESH] |Ovarian Neoplasms/drug therapy/*metabolism/pathology [MESH] |Proteins/*metabolism [MESH] |STAT3 Transcription Factor/metabolism [MESH] |Signal Transduction/*drug effects [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH] |Wnt Proteins/metabolism [MESH] |Xenograft Model Antitumor Assays [MESH]Niclosamide and its analogs are potent inhibitors of Wnt/?-catenin, mT(epmc).pdf DeepDyve Pubget Overpricing