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10.18632/oncotarget.13365 http://scihub22266oqcxt.onion/10.18632/oncotarget.13365 C5349907!5349907!27863390     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (52): 86198-210 Nephropedia Template TP {{tp|p=27863390|t=2016. Suppression of hepatic stellate cell activation through downregulation of gremlin1 expression by the miR-23b/27b cluster |pdf=|usr=}}{{27863390}} gab.com Text Suppression of hepatic stellate cell activation through downregulation of gremlin1 expression by the miR-23b/27b cluster JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27863390 #FOAvip The imbalance between transforming growth factor ? and bone morphogenetic protein 7 signaling pathways is a critical step in promoting hepatic stellate cell activation during hepatic fibrogenesis. Gremlin1 may impair the balance. Something remains unclear about the regulatory mechanisms of gremlin1 action on hepatic stellate cell activation and hepatic fibrosis. In the current study, gremlin1 overexpression promotes activation of hepatic stellate cells. Knockdown of gremlin1 with siRNAs suppresses hepatic stellate cell activation and attenuates hepatic fibrosis in rat model. Our results also show that miR-23b/27b cluster members bind to 3?-untranslated region of gremlin1 resulting in reduction of transforming growth factor ?, ?-smooth muscle actin and collagenI ?1/2 gene expression. Our findings suggest that gremlin1 promotes hepatic stellate cell activation and hepatic fibrogenesis through impairment of the balance between transforming growth factor ? and bone morphogenetic protein 7 signaling pathways. The miR-23b/27b cluster suppresses activation of hepatic stellate cells through binding gremlin1 to rectify the imbalance. Twit Text FOAVip Suppression of hepatic stellate cell activation through downregulation of gremlin1 expression by the miR-23b/27b cluster ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27863390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27863390 #FOAvip English Wikipedia <ref>{{Cite pmid|27863390}}</ref> Suppression of hepatic stellate cell activation through downregulation of gremlin1 expression by the miR-23b/27b cluster #MMPMID27863390 Zeng XY; Zhang YQ; He XM; Wan LY; Wang H; Ni YR; Wang J; Wu JF; Liu CB Oncotarget 2016[Dec]; 7 (52): 86198-210 PMID27863390show ga The imbalance between transforming growth factor ? and bone morphogenetic protein 7 signaling pathways is a critical step in promoting hepatic stellate cell activation during hepatic fibrogenesis. Gremlin1 may impair the balance. Something remains unclear about the regulatory mechanisms of gremlin1 action on hepatic stellate cell activation and hepatic fibrosis. In the current study, gremlin1 overexpression promotes activation of hepatic stellate cells. Knockdown of gremlin1 with siRNAs suppresses hepatic stellate cell activation and attenuates hepatic fibrosis in rat model. Our results also show that miR-23b/27b cluster members bind to 3?-untranslated region of gremlin1 resulting in reduction of transforming growth factor ?, ?-smooth muscle actin and collagenI ?1/2 gene expression. Our findings suggest that gremlin1 promotes hepatic stellate cell activation and hepatic fibrogenesis through impairment of the balance between transforming growth factor ? and bone morphogenetic protein 7 signaling pathways. The miR-23b/27b cluster suppresses activation of hepatic stellate cells through binding gremlin1 to rectify the imbalance. äSuppression of hepatic stellate cell activation through downregulation(epmc).pdf DeepDyve Pubget Overpricing