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An early-screening biomarker of endometrial carcinoma: NGAL is associated with
epithelio-mesenchymal transition
#MMPMID27863382
Li T
; Yu L
; Wen J
; Liao Q
; Liu Z
Oncotarget
2016[Dec]; 7
(52
): 86064-86074
PMID27863382
show ga
Neutrophil gelatinase-associated lipocalin is currently one of the most
interesting and enigmatic proteins involved in the development of malignancies.
In this study, we found that the expression of neutrophil gelatinase-associated
lipocalin was up-regulated in endometrial cancer tissues and cell lines,
significantly increased in early-grade ones, suggesting it may serve as a
biomarker for early-stage screening for endometrial carcinoma. Moreover,
neutrophil gelatinase-associated lipocalin was up-regulated in Ishikawa cells
under going epithelio-mesenchymal transition induced by epidermal growth factor
(5 ng/ml). Up-regulation of neutrophil gelatinase-associated lipocalin may
correlate with the down-regulation of E-cadherin expression, up-regulation of
Vimentin expression, enhanced cell migration, invasion and proliferation, which
are the typical hallmarks of epithelio-mesenchymal transition processes.
Neutrophil gelatinase-associated lipocalin may play a dual role during
tumorigenetic and developmental processes of endometrial carcinoma. These results
suggested neutrophil gelatinase-associated lipocalin to be a potential molecular
target in the early diagnosis and treatment of endometrial carcinoma. Further
studies are warranted to clarify the molecular mechanisms behind the expression
and function of neutrophil gelatinase-associated lipocalin and
epithelio-mesenchymal transition.
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