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10.1089/ars.2015.6409 http://scihub22266oqcxt.onion/10.1089/ars.2015.6409 C5349223!5349223!26715031     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antioxid+Redox+Signal 2016 ; 24 (12): 620-34 Nephropedia Template TP {{tp|p=26715031|t=2016. Regulation of Posttranslational Modifications of HMGB1 During Immune Responses |pdf=|usr=}}{{26715031}} gab.com Text Regulation of Posttranslational Modifications of HMGB1 During Immune Responses JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=26715031 #FOAvip Significance: High-mobility group protein 1 (HMGB1) is an evolutionarily conserved and multifunctional protein. The biological function of HMGB1 depends on its cellular locations, binding partners, and redox states. Extracellular HMGB1 is a mediator of inflammation during infection or tissue injury. Immune cells actively release HMGB1 in response to infection, which in turn orchestrates both innate and adaptive immune responses. Recent Advances: Hyperacetylation of HMGB1 within its nuclear localization sequences mobilizes HMGB1 from the nucleus to the cytoplasm and subsequently promotes HMGB1 release. The redox states of the cysteines in positions 23, 45, and 106 determine the biological activity of the extracellular HMGB1. Critical Issues: The full picture and the detailed molecular mechanisms of how cells regulate the posttranslational modifications and the redox status of HMGB1 during immune responses or under stress not only unravel the molecular mechanisms by which cells regulate the release and the biological function of HMGB1 but may also provide novel therapeutic targets to treat inflammatory diseases. Future Directions: It is important to identify the signaling pathways that regulate the posttranslational modifications and the redox status of HMGB1 and find their roles in host immune responses and pathogenesis of diseases. Antioxid. Redox Signal. 24, 620?634. Twit Text FOAVip Regulation of Posttranslational Modifications of HMGB1 During Immune Responses ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=26715031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26715031 #FOAvip English Wikipedia <ref>{{Cite pmid|26715031}}</ref> Regulation of Posttranslational Modifications of HMGB1 During Immune Responses #MMPMID26715031 Tang Y; Zhao X; Antoine D; Xiao X; Wang H; Andersson U; Billiar TR; Tracey KJ; Lu B Antioxid Redox Signal 2016[Apr]; 24 (12): 620-34 PMID26715031show ga Significance: High-mobility group protein 1 (HMGB1) is an evolutionarily conserved and multifunctional protein. The biological function of HMGB1 depends on its cellular locations, binding partners, and redox states. Extracellular HMGB1 is a mediator of inflammation during infection or tissue injury. Immune cells actively release HMGB1 in response to infection, which in turn orchestrates both innate and adaptive immune responses. Recent Advances: Hyperacetylation of HMGB1 within its nuclear localization sequences mobilizes HMGB1 from the nucleus to the cytoplasm and subsequently promotes HMGB1 release. The redox states of the cysteines in positions 23, 45, and 106 determine the biological activity of the extracellular HMGB1. Critical Issues: The full picture and the detailed molecular mechanisms of how cells regulate the posttranslational modifications and the redox status of HMGB1 during immune responses or under stress not only unravel the molecular mechanisms by which cells regulate the release and the biological function of HMGB1 but may also provide novel therapeutic targets to treat inflammatory diseases. Future Directions: It is important to identify the signaling pathways that regulate the posttranslational modifications and the redox status of HMGB1 and find their roles in host immune responses and pathogenesis of diseases. Antioxid. Redox Signal. 24, 620?634. äRegulation of Posttranslational Modifications of HMGB1 During Immune R(epmc).pdf DeepDyve Pubget Overpricing