Evolutionary rewiring of bacterial regulatory networks #MMPMID28357301
Taylor TB; Mulley G; McGuffin LJ; Johnson LJ; Brockhurst MA; Arseneault T; Silby MW; Jackson RW
Microb Cell ä[]; 2 (7): 256-8 PMID28357301show ga
Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive homology between components of different networks, due to past cycles of gene duplication, divergence, and horizontal gene transfer, raising the possibility of cross-talk or redundancy. Consequently, evolutionary resilience is built into gene networks - homology between regulators can potentially allow rapid rescue of lost regulatory function across distant regions of the genome. In our recent study [Taylor, et al. Science (2015), 347(6225)] we find that mutations that facilitate cross-talk between pathways can contribute to gene network evolution, but that such mutations come with severe pleiotropic costs. Arising from this work are a number of questions surrounding how this phenomenon occurs.
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Microb+Cell ä ; 2 (7): 256-8
